ArticleCureus2026
Assessment of Hepatitis B Vaccination, Awareness, and Seroprotection Among Healthcare and Support Staff in a Tertiary Care Center in Central India.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
introductionHepatitis B vaccination is a key strategy for preventing occupationally acquired hepatitis B virus infection among healthcare workers. However, variability in vaccination coverage, awareness, and post-vaccination serological monitoring persists across different professional groups in healthcare settings. This study assessed hepatitis B vaccination status, awareness, and seroprotection among healthcare and support staff in a tertiary care center in Central India.
methodsA prospective cross-sectional observational study was conducted from January to June 2025 among healthcare workers and support staff at a tertiary care teaching hospital. Sociodemographic details, vaccination history, occupational exposure, and awareness were collected using a structured questionnaire. Serum anti-hepatitis B surface antibody levels were measured using an enzyme-linked immunosorbent assay. Seroprotection was defined as anti-HBs ≥ 10 mIU/mL. Associations were assessed using chi-square tests, and multivariate logistic regression was performed to identify predictors of seroprotection.
resultsA total of 676 participants were enrolled, including 429 (63.5%) healthcare workers and 247 (36.5%) support staff. Overall, 328 (48.5%) participants were fully vaccinated, 26 (3.8%) were partially vaccinated, and 322 (47.6%) were unvaccinated. The overall seroprotection rate was 359 (53.1%). Healthcare workers demonstrated higher vaccination coverage and seroprotection compared with support staff. Among fully vaccinated participants, 288 (87.8%) achieved seroprotection, while 40 (12.2%) were non-responders. Natural immunity was observed in a subset of unvaccinated participants. Vaccination status was the strongest independent predictor of seroprotection, and increasing age was associated with lower antibody response among fully vaccinated individuals. Self-reported vaccination awareness showed a significant association with verified seroprotection.
conclusionHepatitis B vaccination coverage and seroprotection varied across professional groups, with comparatively lower levels among support staff. Strengthening inclusive occupational health strategies, improving vaccination documentation, and promoting post-vaccination antibody assessment may further enhance workforce protection in tertiary care settings.
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