Evidence map›Paper›PMID 41835567›Full record

ArticleACS omega2026

Structure-Based Design of Reversible, Quinoline-2(1

Lian M C Jacobs, Priyadarshini Jaishankar, Jeffrey Zheng, Eric R Hantz, Isabel Lee, Krishna Narramneni, Nicholas Poore, Nathanial Torres, Jessica K Jackson, Oriana Williams and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Lian M C JacobsDepartment of Molecular Medicine, University of South Florida College of Medicine, 12901 Bruce B. Downs Boulevard, MDC 3522, Tampa, Florida 33612, United States.
Priyadarshini JaishankarDepartment of Pharmaceutical Chemistry, University of California San Francisco, 600 16th Street, Genentech Hall N574, San Francisco, California 94158, United States.
Jeffrey ZhengDepartment of Pharmaceutical Chemistry, University of California San Francisco, 600 16th Street, Genentech Hall N574, San Francisco, California 94158, United States.ORCID https://orcid.org/0000-0002-4691-9317
Eric R HantzDepartment of Pharmaceutical Chemistry, University of California San Francisco, 600 16th Street, Genentech Hall N574, San Francisco, California 94158, United States.ORCID https://orcid.org/0000-0002-2588-7619
Isabel LeeDepartment of Pharmaceutical Chemistry, University of California San Francisco, 600 16th Street, Genentech Hall N574, San Francisco, California 94158, United States.
Krishna NarramneniDepartment of Molecular Medicine, University of South Florida College of Medicine, 12901 Bruce B. Downs Boulevard, MDC 3522, Tampa, Florida 33612, United States.
Nicholas PooreDepartment of Molecular Medicine, University of South Florida College of Medicine, 12901 Bruce B. Downs Boulevard, MDC 3522, Tampa, Florida 33612, United States.
Nathanial TorresDepartment of Molecular Biosciences, University of South Florida, 4202 East Fowler Avenue, Tampa, Florida 33620, United States.
Jessica K JacksonDepartment of Molecular Biosciences, University of South Florida, 4202 East Fowler Avenue, Tampa, Florida 33620, United States.
Oriana WilliamsDepartment of Molecular Medicine, University of South Florida College of Medicine, 12901 Bruce B. Downs Boulevard, MDC 3522, Tampa, Florida 33612, United States.
Sophie E DarchDepartment of Molecular Medicine, University of South Florida College of Medicine, 12901 Bruce B. Downs Boulevard, MDC 3522, Tampa, Florida 33612, United States.ORCID https://orcid.org/0000-0003-2800-2844
Lindsey N ShawDepartment of Molecular Biosciences, University of South Florida, 4202 East Fowler Avenue, Tampa, Florida 33620, United States.ORCID https://orcid.org/0000-0002-0629-8990
Yu ChenDepartment of Molecular Medicine, University of South Florida College of Medicine, 12901 Bruce B. Downs Boulevard, MDC 3522, Tampa, Florida 33612, United States.ORCID https://orcid.org/0000-0002-5115-3600
Adam R RensloDepartment of Pharmaceutical Chemistry, University of California San Francisco, 600 16th Street, Genentech Hall N574, San Francisco, California 94158, United States.ORCID https://orcid.org/0000-0002-1240-2846

Funding

Evolution and inhibition of carbapenemase in beta-lactam resistanceR01AI161762 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI CHEN, YU, RENSLO, ADAM R · 2021 to 2025
$3.7M
NIAID NIH HHS R01 AI161762
6 · The paper itself

Abstract

Carbapenems are essential β-lactam antibiotics whose clinical utility is now threatened by emerging carbapenemases, including the Class A serine β-lactamase KPC-2 and the Class B metallo-β-lactamase NDM-1. Here, we describe a comprehensive, structure-based assessment of active-site binding determinants for KPC-2 and NDM-1 in the context of reversible, noncovalent inhibition by a quinoline-2-(1

Identifiers

PMID41835567
PMCPMC12980412

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.