Evidence map›Paper›PMID 41835463›Full record

ArticleFrontiers in cardiovascular medicine2026

Recent findings on the global, regional, and national burden of lower extremity peripheral arterial disease in the elderly (1990-2021): an analysis based on the global burden of disease study 2021.

Chenghao Yang, Sheng Fang, Xu Li, Ming Wang, Tianchen Xie, Zhenyu Zhou, Yong Ding, Min Zhou, Zhenyu Shi

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Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Chenghao Yang *Department of Vascular Surgery, National Clinical Research Center for Interventional Medicine, Zhongshan Hospital, Institute of Vascular Surgery, Fudan University, Shanghai, China.
Sheng Fang *Department of Vascular Surgery, National Clinical Research Center for Interventional Medicine, Zhongshan Hospital, Institute of Vascular Surgery, Fudan University, Shanghai, China.
Xu Li *Department of Vascular Surgery, National Clinical Research Center for Interventional Medicine, Zhongshan Hospital, Institute of Vascular Surgery, Fudan University, Shanghai, China.
Ming WangDepartment of Vascular Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
Tianchen XieDepartment of Vascular Surgery, National Clinical Research Center for Interventional Medicine, Zhongshan Hospital, Institute of Vascular Surgery, Fudan University, Shanghai, China.
Zhenyu ZhouDepartment of Vascular Surgery, National Clinical Research Center for Interventional Medicine, Zhongshan Hospital, Institute of Vascular Surgery, Fudan University, Shanghai, China.
Yong DingDepartment of Vascular Surgery, National Clinical Research Center for Interventional Medicine, Zhongshan Hospital, Institute of Vascular Surgery, Fudan University, Shanghai, China.
Min ZhouDepartment of Vascular Surgery, National Clinical Research Center for Interventional Medicine, Zhongshan Hospital, Institute of Vascular Surgery, Fudan University, Shanghai, China.
Zhenyu ShiDepartment of Vascular Surgery, National Clinical Research Center for Interventional Medicine, Zhongshan Hospital, Institute of Vascular Surgery, Fudan University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Lower extremity peripheral arterial disease (LEPAD) significantly impacts the elderly population, with increasing prevalence globally. This study analyzes the global, regional, and national burden of LEPAD in individuals aged 60 and above from 1990 to 2021, using data from the Global Burden of Disease Study 2021. Methods: We examined age-standardized prevalence rates (ASPR), incidence rates (ASIR), and disability-adjusted life years (DALYs) across 204 countries. Trends over time were assessed using Estimated Annual Percentage Change (EAPC), and future projections were made through a Bayesian age-period-cohort model. Results: In 2021, the elderly population experienced 87.5 million LEPAD cases, a 105.5% increase since 1990. ASPR declined slightly (EAPC: -0.52) despite rising absolute cases, reflecting aging populations. High SDI regions had the highest prevalence but also the greatest reductions over time. Regional disparities were notable, with Eastern and Central Europe facing the highest DALYs. Projections to 2040 suggest continued increases in LEPAD burden, with gender disparities persisting. Conclusion: LEPAD remains a growing global health challenge, driven by aging populations. Targeted interventions are needed, particularly in low-middle SDI regions, to address the escalating burden of LEPAD among the elderly.

Indexed as

disability-adjusted life yearsglobal burden of diseaseincidencelower extremity peripheral arterial diseaseprevalence

Identifiers

PMID41835463
PMCPMC12980402

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