Evidence map›Paper›PMID 41835410›Full record

SynthesisFrontiers in public health2026

Non-cancer mortality among firefighters: a meta-analytic review of heart disease, stroke, respiratory disease, liver disease, accidents, and suicide.

Paulo S Pinheiro, Soyeon Ahn, Stephanie Negron, Victoria Pinilla, Erin N Kobetz, Alberto J Caban-Martinez, David J Lee

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Paulo S PinheiroDepartment of Public Health Sciences, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, United States.
Soyeon AhnDepartment of Education and Psychological Studies, University of Miami, Miami, FL, United States.
Stephanie NegronDepartment of Public Health Sciences, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, United States.
Victoria PinillaDepartment of Public Health Sciences, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, United States.
Erin N KobetzSylvester Comprehensive Cancer Center, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, United States.
Alberto J Caban-MartinezDepartment of Public Health Sciences, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, United States.
David J LeeDepartment of Public Health Sciences, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Firefighting is a hazardous occupation linked to elevated cancer risk. However, occupational exposures unique to this profession may also contribute to non-cancer morbidity and mortality. To better understand firefighters' health risks, it is essential to examine causes of death beyond cancer. Methods: Following PRISMA guidelines, we conducted a systematic review and meta-analysis of population-based studies published between 1978 and 2025. Studies reporting standardized mortality ratios (SMRs) for non-cancer causes of death were identified through database searches. We estimated pooled SMRs and 95% confidence intervals using random-effects models, tested for publication bias and study quality, and conducted moderator analyses. Results: Twenty-five studies were included for final meta-analysis. Firefighters exhibited significantly lower mortality rate for heart disease (SMR = 0.64; 95%CI: 0.51-0.80), cerebrovascular disease (SMR = 0.67; 95%CI: 0.50-0.90), diabetes mellitus (SMR = 0.48; 95%CI: 0.32-0.70), intentional self-harm/suicide (SMR = 0.52; 95%CI: 0.39-0.70), chronic lower respiratory disease (SMR = 0.71; 95%CI: 0.55-0.91), and accidents/injuries (SMR = 0.77; 95%CI: 0.62-0.98) compared to the general population. In contrast, evidence for respiratory infections ( Conclusion: Firefighters experience lower mortality from multiple non-cancer causes, potentially due to occupational fitness requirements and the healthy worker effect. However, parity in mortality from liver disease and pneumonia/influenza warrant further investigation into behavioral factors and occupational exposures. Our results refine the healthy worker effect by identifying cause-specific gaps and priorities for targeted prevention and surveillance.

Indexed as

FirefightersNoncommunicable DiseasesOccupational DiseasesSuicideCause of DeathHeart DiseasesHumansLiver DiseasesOccupational ExposureRespiratory Tract DiseasesStrokeaccidentscause of deathfirefightersheart diseaseliver diseasemortalityrespiratory diseasestroke

Identifiers

PMID41835410
PMCPMC12979482

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.