ArticleFrontiers in surgery2026
Tranexamic acid combined with fluid gelatin in perioperative blood loss management of total hip arthroplasty for elderly femoral neck fractures: a single-center retrospective analysis.
Article in Frontiers in surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: Tranexamic acid (TXA) and fluid gelatin (FG) are widely used to reduce perioperative blood loss in total hip arthroplasty (THA). However, the efficacy of single-method hemostatic strategies is increasingly insufficient for meeting clinical demands. The aim of this study was to evaluate the efficacy of TXA in combination with FG for perioperative blood management. Methods: This retrospective study enrolled 301 patients with unilateral femoral neck fractures who underwent minimally invasive piriformis approach total hip arthroplasty (between 2019 and 2023) and received hemostatics. Patients were divided into TXA ( Results: The clinical results of 408 patients indicated that the combination of TXA and FG significantly reduced perioperative blood loss in THA via MIS-TPA (550.68 ± 327.61 mL in the TXA + FG group, 732.50 ± 362.84 mL in the TXA group, 817.19 ± 375.46 mL in the FG group, and 982.99 ± 428.81 mL in the control group; Conclusion: Combined intravenous TXA and intra-articular FG administration provided superior perioperative blood loss control and did not increase the rate of complications.
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