Evidence map›Paper›PMID 41835246›Full record

ArticleFrontiers in surgery2026

Preoperative Lugol's solution and surgical outcomes in Graves' disease: a single-center retrospective study.

Mehmet Taner Ünlü, Ozan Caliskan, Işık Çetinoğlu, Zerin Şengül, Hazal Arikan, Düşsel Gerçelman, Nurcihan Aygun, Mehmet Uludag

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Article in Frontiers in surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mehmet Taner ÜnlüGeneral Surgery Clinic, Endocrine Surgery Department, Health Science Universty Istanbul Sisli Hamidiye Etfal Training and Research Hospital, Sarıyer, Türkiye.
Ozan CaliskanGeneral Surgery Clinic, Endocrine Surgery Department, Health Science Universty Istanbul Sisli Hamidiye Etfal Training and Research Hospital, Sarıyer, Türkiye.
Işık ÇetinoğluGeneral Surgery Clinic, Endocrine Surgery Department, Health Science Universty Istanbul Sisli Hamidiye Etfal Training and Research Hospital, Sarıyer, Türkiye.
Zerin ŞengülGeneral Surgery Clinic, Endocrine Surgery Department, Health Science Universty Istanbul Sisli Hamidiye Etfal Training and Research Hospital, Sarıyer, Türkiye.
Hazal ArikanGeneral Surgery Clinic, Endocrine Surgery Department, Health Science Universty Istanbul Sisli Hamidiye Etfal Training and Research Hospital, Sarıyer, Türkiye.
Düşsel GerçelmanGeneral Surgery Clinic, Endocrine Surgery Department, Health Science Universty Istanbul Sisli Hamidiye Etfal Training and Research Hospital, Sarıyer, Türkiye.
Nurcihan AygunGeneral Surgery Clinic, Endocrine Surgery Department, Health Science Universty Istanbul Sisli Hamidiye Etfal Training and Research Hospital, Sarıyer, Türkiye.
Mehmet UludagGeneral Surgery Clinic, Endocrine Surgery Department, Health Science Universty Istanbul Sisli Hamidiye Etfal Training and Research Hospital, Sarıyer, Türkiye.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Basedow Graves disease (BG) is the most common cause of hyperthyroidism. Lugol's solution (LS) is used preoperatively to inhibit thyroid hormone production, decrease thyroid gland vascularity and ensure a safer surgical field. This study aims to evaluate efficacy of the LS and its association with surgical complications in patients with BG. Materials and methods: Patients with total thyroidectomy for BG between 2019 and 2024 were retrospectively included. Preoperative calcium (Ca), alkaline phosphatase (ALP), parathyroid hormone (PTH) levels, operative time, resected thyroid specimen weights, postoperative complications were analyzed. Results: Among 128 patients, 38(29.6%) received LS (Group1), while 90 (70.3%) did not (Group2). No significant difference was found between groups regarding preoperative Ca, ALP, PTH ( Conclusion: The primary endpoint of postoperative hypocalcemia/hypoparathyroidism did not differ significantly between groups. Although the incidence of transient hypoparathyroidism was slightly higher in the LS group, no statistically significant difference was observed. Additionally, no significant difference was found regarding intraoperative or long-term outcomes. Present study did not demonstrate a protective effect of preoperative LS on surgical complications in patients with BG.

Indexed as

endemic goiterGraves' diseaseLugol's solutionpreoperative preparationsurgical outcomesthyroidectomy

Identifiers

PMID41835246
PMCPMC12979558

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.