Evidence map›Paper›PMID 41835123›Full record

ArticleJournal of inflammation research2026

Inhibition of Airway Epithelial CTSC Attenuates Type 2 Inflammation: Implications for Eosinophilic Chronic Rhinosinusitis with Nasal Polyps.

Xiayan Li, Zhenchao Zhu, Junlu Zhu, Bingqi Lin, Suizi Zhou, Ruofan Yang, Yitong Liu, Yang Peng, Qianhui Qiu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of inflammation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiayan Li *Department of Otolaryngology-Head and Neck Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, 510080, People's Republic of China.ORCID 0009-0009-4252-3698
Zhenchao Zhu *Department of Otolaryngology-Head and Neck Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, 510080, People's Republic of China.
Junlu Zhu *Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, People's Republic of China.ORCID 0009-0008-8577-9215
Bingqi Lin *State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong, 510030, People's Republic of China.
Suizi ZhouGuangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, People's Republic of China.
Ruofan YangDepartment of Otolaryngology-Head and Neck Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, 510080, People's Republic of China.ORCID 0009-0007-8426-9558
Yitong LiuDepartment of Otolaryngology-Head and Neck Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, 510080, People's Republic of China.ORCID 0000-0002-4478-9440
Yang PengState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong, 510030, People's Republic of China.
Qianhui QiuDepartment of Otolaryngology-Head and Neck Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, 510080, People's Republic of China.ORCID 0000-0001-6335-5173

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Cathepsin C (CTSC) has been identified as a key pathogenic gene in chronic rhinosinusitis. This study aimed to investigate the specific function and subcellular localization of CTSC within the nasal mucosal epithelium. Patients and Methods: A total of 34 patients with eosinophilic chronic rhinosinusitis with nasal polyps (eNP), 32 with non-eosinophilic chronic rhinosinusitis with nasal polyps (neNP), and 16 control subjects were enrolled. Airway epithelial morphology was examined by scanning electron microscopy. The expression, localization, and function of CTSC in epithelial cells were assessed using single-cell RNA sequencing (scRNA-seq), immunohistochemistry, quantitative real-time PCR, Western blot, and an siRNA-mediated knockdown approach in an IL-4/IL-13-stimulated 16HBE cell line model. Results: scRNA-seq revealed that Conclusion: This study identifies CTSC as a novel regulator of type 2 inflammation like eNP. It is specifically upregulated in nasal epithelial goblet and basal cells, highlighting its potential as a therapeutic target for airway diseases.

Indexed as

Cathepsin Ceosinophilic chronic rhinosinusitis with nasal polypsepithelial cellstype 2 inflammation

Identifiers

PMID41835123
PMCPMC12988805

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.