ArticleFrontiers in neurology
Study on brain functional networks and cortical morphological structures in patients with primary insomnia.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: The prevalence of primary insomnia (PI) has been increasing year by year. This study aims to explore its neurobiological mechanisms and provide neuroimaging evidence for clinical diagnosis and treatment. Methods: A total of 33 patients with PI and 25 healthy controls were recruited. All participants completed assessments of sleep status, cognitive function, and evaluations using neuropsychological scales. Voxel-based degree centrality (DC) analysis was used to identify abnormal functional network hubs, and differentially activated brain regions were further used as seed points for whole-brain functional connectivity (FC) analysis. Surface-based morphometry (SBM) was employed to analyze cortical morphological parameters. Additionally, DC values, FC values, and cortical morphological parameters of the differentially activated brain regions were extracted from the PI group for the differentially activated brain regions, and further correlation analyses were performed with neuropsychological scale scores. Results: In patients with PI, the DC of the bilateral precuneus/posterior cingulate gyrus was increased, while the DC of brain regions related to the right parietal lobe was decreased; FC was reduced in some brain regions; the cortex of the left frontoparietal region was thinner with an elevated gyrification index (GI); and the fractal dimension (FD) of the right parieto-occipital cortex/left occipital cortex was decreased. Discussion: PI patients show abnormal functional hubs (posterior DMN, CEN parietal lobe), reduced FC (CEN-right cerebellum, posterior DMN-occipital lobe), and cortical morphological changes (left frontoparietal thinning, etc.). These neuroimaging indices are correlated with patients' sleep quality, which can provide a basis for mechanistic research and clinical diagnosis of PI.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.