ArticleFrontiers in cellular and infection microbiology2026
Clinical characteristics analysis of pertussis and Mycoplasma pneumoniae infection in children.
Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To analyze the clinical differences between pertussis and/or Methods: We retrospectively reviewed children with respiratory symptoms who attended Shandong University Children's Hospital (Jinan, China) from 2019 to 2024 and underwent simultaneous testing for pertussis and MP. Patients were categorized as pertussis-only, MP-only, or dual-positive, and differences in demographics, seasonality, manifestations, hematologic indices, and co-detected pathogens were analyzed. Results: A total of 7184 children were included: 2,982 pertussis-only, 3,166 MP-only, and 1,036 dual-positive. Significant differences were observed in sex (χ² = 30.964), age (χ² = 393.010), and season (χ² = 436.070) (all Conclusion: Pertussis and MP infections in children show distinct demographic, seasonal, clinical, and laboratory patterns. Recognition of these epidemiologic and clinical signatures supports early differentiation at the bedside and the use of multiplex PCR combined with specific laboratory markers to enable more targeted clinical management.
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