Evidence map›Paper›PMID 41834993›Full record

ArticleFrontiers in cellular and infection microbiology2026

E3 ubiquitin ligase SKP2 limits autophagosome formation during

Abhishek K Singh, Madina Baglanova, Eylin Topfstedt, Kristin Surmann, Silva Holtfreter, Leif Steil, Uwe Völker, Michael Lammers, Barbara M Bröker, Karsten Becker and 2 more

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In one paragraph

Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Abhishek K SinghFriedrich Loeffler-Institute of Medical Microbiology, University Medicine Greifswald, Greifswald, Germany.
Madina BaglanovaFriedrich Loeffler-Institute of Medical Microbiology, University Medicine Greifswald, Greifswald, Germany.
Eylin TopfstedtFriedrich Loeffler-Institute of Medical Microbiology, University Medicine Greifswald, Greifswald, Germany.
Kristin SurmannDepartment of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Silva HoltfreterInstitute of Immunology, University Medicine Greifswald, Greifswald, Germany.
Leif SteilDepartment of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Uwe VölkerDepartment of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Michael LammersDepartment of Synthetic and Structural Biochemistry, Institute of Biochemistry, University of Greifswald, Greifswald, Germany.
Barbara M BrökerInstitute of Immunology, University Medicine Greifswald, Greifswald, Germany.
Karsten BeckerFriedrich Loeffler-Institute of Medical Microbiology, University Medicine Greifswald, Greifswald, Germany.
Clemens CammannFriedrich Loeffler-Institute of Medical Microbiology, University Medicine Greifswald, Greifswald, Germany.
Ulrike SeifertFriedrich Loeffler-Institute of Medical Microbiology, University Medicine Greifswald, Greifswald, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Ubiquitination is a posttranslational modification that affects protein function, stability, and localization and is thereby balancing protein homeostasis. During infection, ubiquitination is crucial in regulating host cell signaling pathways in pathogen recognition, clearance and mounting an efficient immune response. Results: We examined the role of the E3 ligase S-phase kinase-associated protein 2 (SKP2), a component of the SKP1-Cullin1-F-box (SCF) - complex, during Conclusion: These findings underscore that SKP2 is an important regulator of autophagosome formation, preventing excessive autophagy from being exploited by

Indexed as

AutophagosomesHost-Pathogen InteractionsS-Phase Kinase-Associated ProteinsStaphylococcal InfectionsStaphylococcus aureusAcetylationAnimalsAutophagyCell LineEpithelial CellsHumansMacrophagesMicrotubule-Associated ProteinsUbiquitinationMicrotubule-Associated ProteinsSKP2 protein, humanS-Phase Kinase-Associated ProteinsE3 ligaseintracellular bacteriaS. aureusselective autophagySKP2

Identifiers

PMID41834993
PMCPMC12982375

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.