ReviewSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition2026
[Research on Bacteriophage Resistance: Coevolutionary Arms Race Between Bacteria and Phages Drives Novel Antibacterial Therapies].
Review in Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
8 authors.
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Abstract
The growing threat of antimicrobial resistance requires the urgent development of new therapeutic strategies and agents. Bacteriophage therapy offers a promising alternative, utilizing phages' ability to specifically recognize and lyse bacterial cells. The ubiquity of bacteriophages subjects bacteria to constant evolutionary pressure, driving the emergence of diverse systems that defend against phage infection. The repertoire of phage defense genes includes a wide range of functions, such as nucleases, helicases, and ATPases. Host-phage interactions are complex and multifaceted. Bacterial defense mechanisms operate at various levels: initial innate defenses that inhibit phage adsorption, block nucleic acid injection, and interfere with virion assembly; early vesicle rupture targeting phage nucleic acids; systems that specifically target phage DNA and RNA; and abortive infection, which results in the degradation of bacterial nucleic acids, depletion of NAD
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.