Evidence map›Paper›PMID 41834976›Full record

ReviewSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition2026

[Research Progress on Quorum Sensing-Regulated Oral Microbial Interaction Networks in Periodontitis].

Lu Li, Zitong Yu, Yan Xu

Abstract readReviewEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Review in Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Isoferulic acid suppressesFrontiers in microbiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Lu Li（ 210029）Department of Periodontics, the Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing 210029, China.ORCID 0000-0002-7302-8528
Zitong Yu（ 210029）Department of Periodontics, the Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing 210029, China.
Yan Xu（ 210029）Department of Periodontics, the Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing 210029, China.ORCID 0000-0002-9975-2215

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Quorum sensing (QS) is a mechanism by which bacteria communicate and coordinate group behaviors through the secretion of signaling molecules, playing a critical role in oral microbial interactions and the pathogenesis of periodontitis. This review summarizes recent advances in QS-mediated regulation of oral microbial interaction networks in periodontitis, focusing on the molecular mechanisms that modulate biofilm formation, virulence factor expression, and pathogen community dynamics. In addition, novel QS-targeted therapeutic strategies are discussed. Although periodontitis is fundamentally a chronic inflammatory disease driven by oral dysbiosis, the precise mechanisms by which microbes trigger and amplify inflammatory damage through the "community dynamics-host interaction-microenvironment" axis remain unclear. Therefore, exploring novel therapeutic strategies targeting the QS system offers potential targets and innovative approaches for the clinical treatment of periodontitis.

Indexed as

DysbiosisMicrobiotaPeriodontitisQuorum SensingBiofilmsHost-Pathogen InteractionsHumansMouthVirulence FactorsVirulence FactorsBiofilmMicrobial interactionsPeriodontitisQuorum sensingReview

Identifiers

PMID41834976
PMCPMC12979981

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.