ArticleSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition2026
[Diagnostic Value of Serological Markers and Quantitative Real-Time PCR in Patients With Invasive Candidiasis].
Article in Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To evaluate the clinical diagnostic value of serological markers, including the 1, 3-β-D-glucan test (G-test), Methods: This study included 79 patients with culture-proven IC (IC group) and 83 patients without IC (non-IC group) at West China Hospital, Sichuan University between December 2022 and December 2024. Serum samples were tested for the G test (chemiluminescence), Mn antigen (ELISA), Mn-IgG (chemiluminescence), and qPCR. The diagnostic sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of individual and combined tests were calculated. Diagnostic performance was assessed using receiver operating characteristic (ROC) curve analysis. Results: The sensitivity, specificity, PPV, and NPV of the three serological markers for IC diagnosis when used individually were as follows: G test, 62.03%, 94.87%, 92.45%, and 71.15%; Mn antigen, 65.63%, 86.59%, 79.25%, and 76.34%; Mn-IgG antibody, 31.65%, 87.95%, 71.43%, and 57.48%. Combined detection of the G test, Mn antigen, and Mn-IgG increased sensitivity to 73.44%. Based on ROC curve analysis, the AUCs for diagnosing IC using each serological marker were: G test, 0.862 (95% CI: 0.803-0.922); Mn test, 0.853 (95% CI: 0.790-0.915); Mn-IgG, 0.603 (95% CI: 0.514-0.692). The combined AUCs for G test + Mn test, G test + Mn-IgG, and G test + Mn test + Mn-IgG were 0.875 (95% CI: 0.809-0.925), 0.869 (95% CI: 0.805-0.917), and 0.875 (95% CI: 0.809-0.924), respectively, demonstrating superiority over individual tests. The sensitivity, specificity, PPV, and NPV of qPCR for IC diagnosis were 100.00%, 98.80%, 98.75%, and 100.00%, respectively. Using culture strain identification by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) as the gold standard, qPCR demonstrated diagnostic concordance rates of 100.00% for Conclusion: The combined use of the G test, Mn antigen, and Mn-IgG antibody increases diagnostic sensitivity and facilitates early diagnosis of IC. qPCR demonstrates excellent diagnostic performance for IC, enabling species-level identification of common
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