ArticleEuropean heart journal. Imaging methods and practice2026
Ischaemia-reperfusion dynamics in acute myocardial infarction experimental swine model: new insights from quantitative CMR.
Article in European heart journal. Imaging methods and practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Aims: To reveal the pattern and dynamics of myocardial oedema induced by myocardial infarction (MI) during ischaemia and subsequent reperfusion, that remain largely unknown, as are the factors that contribute to reperfusion injury. To propose a time-resolved dynamic myocardial tissue characterization by quantitative CMR, with T1&T2 mapping and Pixel-wise standardized analysis to circumvent inter-animal differences and subjective ROI positioning. Methods and results: We measured T1&T2 relaxation times at baseline, during a 40-min transient coronary occlusion, and after reperfusion in an open-chest swine MI model ( Conclusion: Objective quantification of tissue response by pixel-wise analysis demonstrated rapid and significant changes in myocardial water content status post-reperfusion, with three different early-reperfusion patterns observed, suggesting distinct reperfusion mechanisms. The water content after reperfusion does not reflect its state before and it does not provide insight into the final tissue status observed within 3 h after recanalization.
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