Evidence map›Paper›PMID 41834902›Full record

ArticleFrontiers in human neuroscience2026

Enhanced pitch centering in individuals with laryngeal dystonia.

Rabab Rangwala, Anantajit Subrahmanya, Kurtis Brent, Saloni Gupta, Kamalini Ranasinghe, Corby L Dale, Jessica L Gaines, Alvincé L Pongos, Clark A Rosen, Sarah L Schneider and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in human neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Rabab Rangwala *Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States.
Anantajit Subrahmanya *Department of Electrical and Computer Engineering, University of California, Santa Barbara, Santa Barbara, CA, United States.
Kurtis BrentUniversity of California, Berkeley - University of California, San Francisco Graduate Program in Bioengineering, San Francisco, CA, United States.
Saloni GuptaDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States.
Kamalini RanasingheDepartment of Neurology, University of California, San Francisco, San Francisco, CA, United States.
Corby L DaleDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States.
Jessica L GainesUniversity of California, Berkeley - University of California, San Francisco Graduate Program in Bioengineering, San Francisco, CA, United States.
Alvincé L PongosUniversity of California, Berkeley - University of California, San Francisco Graduate Program in Bioengineering, San Francisco, CA, United States.
Clark A RosenDepartment of Otolaryngology - Head and Neck Surgery, University of California, San Francisco, San Francisco, CA, United States.
Sarah L SchneiderDepartment of Otolaryngology - Head and Neck Surgery, University of California, San Francisco, San Francisco, CA, United States.
Julie Barkmeier-KraemerDepartment of Otolaryngology - Head and Neck Surgery, The University of Utah, Salt Lake City, UT, United States.
Kristina SimonyanDepartment of Otolaryngology - Head and Neck Surgery, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, United States.
John F HoudeDepartment of Otolaryngology - Head and Neck Surgery, University of California, San Francisco, San Francisco, CA, United States.
Srikantan S NagarajanDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States.

Funding

The role of the cerebellum in speechR01DC017091 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI John Francis Houde, RICHARD IVRY · 2019 to 2026
$4.5M
Dynamic Brain Imaging of Speech in Primary Progressive AphasiaR01NS100440 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI, John Francis Houde · 2017 to 2026
$3.6M
Dynamic Brain Imaging of Speech in Primary Progressive AphasiaRF1NS100440 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORNO TEMPINI, MARIA LUISA, HOUDE, JOHN FRANCIS · 2023 to 2023
$2.4M
Dopamine and sensorimotor function in stutteringR21DC021557 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HOUDE, JOHN FRANCIS, MAX, LUDO · 2024 to 2024
$464k
NIDCD NIH HHS R01 DC017091NIDCD NIH HHS R21 DC021557NINDS NIH HHS R01 NS100440NINDS NIH HHS RF1 NS100440
6 · The paper itself

Abstract

Introduction: Laryngeal dystonia (LD) is a neurological voice disorder marked by strained voice quality, pitch instability, and sudden voice breaks, yet the mechanisms underlying impaired vocal control are poorly understood. One key process, known as pitch centering, reflects the central nervous system's ability to correct early pitch deviations during an utterance by converging toward an intended target. While pitch centering provides a sensitive window into the neural control of spontaneous speech, it remains unexamined in patients with LD and is presumed to contribute to disordered regulation of voice production. Methods: Here, we examined pitch centering in 24 individuals with LD [adductor LD ( Results: Initial pitch deviation ( Discussion: These findings offer valuable insights into speech motor and predictive control processes in LD, with potential implications for clinical assessment and treatment strategies aimed at improving patient quality of life.

Indexed as

auditory feedbacklaryngeal dystoniapitch centeringspeech motor controlspeech perceptionspeech production

Identifiers

PMID41834902
PMCPMC12979472

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.