ArticleArchives of rehabilitation research and clinical translation2026
Neural Effects of Low-Frequency Acupoint Electrical Stimulation Therapy on Patients With Poststroke Motor Dysfunction: A Resting-State Functional Magnetic Resonance Imaging Study.
Article in Archives of rehabilitation research and clinical translation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To investigate differences in brain functional activity between patients with poststroke motor dysfunction and healthy individuals, and to examine the effects of low-frequency acupoint electrical stimulation on brain regional homogeneity (ReHo) in patients. Design: This was a case-control study. Setting: The study was conducted in a local tertiary hospital. Participants: Twenty-eight patients with poststroke motor dysfunction (infarcts in the right basal ganglia region; 19 men, 9 women; mean age 59.07±9.03y) were recruited to form the Treatment group (Tx). Concurrently, 20 age- and gender-matched healthy controls (HCs) were recruited (14 men and 6 women, with an average age of 57.60±8.36y). Interventions: The Tx received low-frequency acupoint electrical stimulation. Scalp Acupoint Selection: motor area on the affected hemisphere. Limb Acupoint Selection: acupoints on the affected limb, forming the following pairs: Shousanli (LI10) - Waiguan (SJ5); Ximen (PC4) - Neiguan (PC6); Zusanli (ST36) - Shangjuxu (ST37); and Heyang (BL55) - Chengshan (BL57). Head: frequency 2 Hz, pulse width 100 µs, and intensity 1.5 mA. Upper limb: frequency 35 Hz, pulse width 200 µs, and intensity 40 mA. Lower limb: frequency 50 Hz, pulse width 400 µs, and intensity 40 mA. Each session lasted 30 minutes, administered once daily for 6 sessions per week over 3 weeks. Main Outcome Measures: The primary endpoint was the improvement from baseline in ReHo for patients with stroke at 3 weeks. Results: Compared with HCs, patients with stroke showed increased ReHo in the bilateral parahippocampal gyrus, bilateral cerebellum, and cerebellar vermis, whereas ReHo decreased in sensorimotor network (SMN)-related brain regions (false discovery rate [FDR]-corrected, Conclusions: Abnormal synchrony between SMN and cerebellum may be a key pathologic feature in poststroke motor dysfunction. Lateralized SMN functional remodeling is a potential neural mechanism for motor recovery via low-frequency acupoint electrical stimulation.
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