Evidence map›Paper›PMID 41834407›Full record

SynthesisJournal of surgical oncology2026

Survival Following Colorectal Cancer Surgery in Low- and Middle-Income Countries: A Systematic Review and Meta-Analysis.

Oluwasegun Afolaranmi, Thomas M Diehl, Sehar Salim Virani, Qiuyu Yang, Leslie Christensen, Kenechukwu Okwunze, Adel H Khan, Nabiha Akhlaq Mughal, Daniel Schroeder, Sheida Pourdashti and 2 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Oluwasegun AfolaranmiDepartment of Surgery, Mayo Clinic, Rochester, Minnesota, USA.ORCID https://orcid.org/0000-0003-2239-7857
Thomas M DiehlDepartment of Surgery, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Sehar Salim ViraniDepartment of Surgery, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Qiuyu YangDepartment of Surgery, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Leslie ChristensenEbling Library for the Health Sciences, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, USA.
Kenechukwu OkwunzeGillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA.
Adel H KhanDepartment of Anesthesiology and Critical Care, Houston Methodist Hospital, Houston, Texas, USA.
Nabiha Akhlaq MughalDepartment of Surgery, Aga Khan University, Karachi, Sindh, Pakistan.
Daniel SchroederDepartment of Radiology, Aurora St. Luke's Medical Center, Milwaukee, Wisconsin, USA.
Sheida PourdashtiSchool of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, USA.
Sadaf KhanDepartment of Surgery, Aga Khan University, Karachi, Sindh, Pakistan.
Syed Nabeel ZafarDepartment of Surgery, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesSurgery is the mainstay of treatment for localized colorectal cancer (CRC); however, little is known about survival outcomes following CRC surgery in low- and middle-income countries (LMICs). Here, we examine the available data on long-term outcomes following CRC resections in LMICs.

methodsA systematic review and meta-analysis were conducted on primary research studies reporting survival data after CRC resection with curative intent in LMICs. Disease-free survival (DFS) and overall survival (OS) data were extracted, and random effects modelling was used to estimate the pooled survival rates.

resultsOne hundred and fifty-four studies representing 20,589 CRC patients were analyzed. Notably, only 27 (20%) of the 137 LMICs were represented in the literature. The pooled 5-year OS estimate was 88% (95% CI: 77-95), 76% (69-81), and 57% (49-64) for Stages I, II, and III, respectively. 5-year DFS estimates were 82% (71-90), 76% (67-84), and 59% (51-65) for stages I, II, and III, respectively. Combined OS and DFS estimates for all three stages were 76% and 69%, respectively. Survival rates varied considerably across the included studies and between income groups.

conclusionsWith the rising incidence of CRC globally, our work highlights the dearth of data on long-term outcomes following CRC operations in most LMICs and emphasizes the urgent need for research capacity building.

Indexed as

Colorectal NeoplasmsDeveloping CountriesColorectal Surgical ProceduresHumansResource-Limited SettingsSurvival Ratecolorectal cancerlow‐ and middle‐income countriessurvival

Identifiers

PMID41834407
PMCPMC13352226

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.