Evidence map›Paper›PMID 41834285›Full record

ArticleAdvanced healthcare materials2026

Sprayable Polymer Blends With Short-Chain Surface Segregation for Preventing Postoperative Abdominal Adhesions.

Robert J Morris, Tejaswi Nori, Alex I Halpern, Hannah LaPadula, Arthur V Cresce, Sarah L Wright, Anthony D Sandler, Peter Kofinas

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Robert J MorrisDepartment of Chemical and Biomolecular Engineering, University of Maryland, College Park, Maryland, USA.
Tejaswi NoriDepartment of Chemical and Biomolecular Engineering, University of Maryland, College Park, Maryland, USA.
Alex I HalpernSheikh Zayed Institute For Pediatric Surgical Innovation, Joseph E. Robert Jr. Center for Surgical Care, Children's National Medical Center, Washington, District of Columbia, USA.
Hannah LaPadulaDepartment of Chemical and Biomolecular Engineering, University of Maryland, College Park, Maryland, USA.
Arthur V CresceU.S. Army DEVCOM Army Research Laboratory, Battery Science Branch, Energy Sciences Division, Adelphi, Maryland, USA.
Sarah L WrightSheikh Zayed Institute For Pediatric Surgical Innovation, Joseph E. Robert Jr. Center for Surgical Care, Children's National Medical Center, Washington, District of Columbia, USA.
Anthony D SandlerSheikh Zayed Institute For Pediatric Surgical Innovation, Joseph E. Robert Jr. Center for Surgical Care, Children's National Medical Center, Washington, District of Columbia, USA.
Peter KofinasDepartment of Chemical and Biomolecular Engineering, University of Maryland, College Park, Maryland, USA.ORCID https://orcid.org/0000-0001-6657-3037

Funding

National Institute of General Medical Sciences of the National Institutes of Health R01GM141132
6 · The paper itself

Abstract

Adhesions are common post-surgical complications where fibrous tissue bridges adjacent surfaces following tissue injury. Although Seprafilm is a widely used clinical prophylactic, it often proves inadequate due to suboptimal mechanical stability and applicability. Solution Blow Spinning (SBS) enables the formation of polymer fibers tailored to complex geometries with excellent tissue adherence. Poly(D,L-lactide-co-caprolactone) (PLCL) polymer has shown promise as an adhesions barrier but remains inconsistent because of its inherent tackiness and hydrophobicity. Here, high molecular weight (HMW) PLCL (40 or 80 kDa) was blended with low molecular weight (LMW) polyethylene glycol (PEG, 1 or 3 kDa). In vitro studies confirmed that PLCL/PEG fibers achieved tissue adhesion strengths above 10 kPa and sustained mechanical performance throughout clinically relevant degradation timelines. Blending PEG changes the surface composition of the spray-deposited mats, substantially improving the hydrophilic character and lowering protein adherence in vitro. In a murine cecal ligation model, the PLCL/PEG blends demonstrated significantly reduced adhesion severity and incidence compared to both untreated and Seprafilm-treated controls.

Indexed as

AbdomenPolyestersPolymersPostoperative ComplicationsAnimalsHyaluronic AcidMicePolyethylene GlycolsSurface PropertiesTissue AdhesionsHyaluronic Acidlactide-caprolactone copolymerPolyestersPolyethylene GlycolsPolymersSeprafilmadhesion barriersprayable polymersurface segregationtissue adhesive

Identifiers

PMID41834285
PMCPMC13206380

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.