Evidence map›Paper›PMID 41834240›Full record

ReviewBioEssays : news and reviews in molecular, cellular and developmental biology2026

Vimentin Intermediate Filaments: A Paradigm Shift From Static Structure to Dynamic Cytoplasmic Network.

Bhuvanasundar Renganathan, Stephen A Adam, Vladimir I Gelfand

Abstract readReview
In one paragraph

Review in BioEssays : news and reviews in molecular, cellular and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Bhuvanasundar RenganathanDepartment of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, USA.
Stephen A AdamDepartment of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, USA.
Vladimir I GelfandDepartment of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, USA.

Funding

NIGMS NIH HHS
6 · The paper itself

Abstract

Recent advances in live-cell imaging, super-resolution microscopy, labeling techniques and cryo-electron microscopy reveal vimentin intermediate filaments (VIFs) as adaptable polymers that couple mechanical stability with rapid remodeling. In this review, we highlight recent findings and discuss how VIFs function as dynamic, interpenetrating networks with actin microfilaments and microtubules, coordinating cytoskeletal architecture while simultaneously facilitating organelle positioning and influencing cellular behavior. We also propose a hybrid transport model to capture the diverse modes of VIF cellular interactions. This emerging framework positions VIFs as dynamic integrators of cytoskeletal organization and intracellular logistics, with broad implications for understanding cell mechanics, migration, and disease.

Indexed as

CytoplasmIntermediate FilamentsVimentinActin CytoskeletonAnimalsCytoskeletonHumansMicrotubulesVimentincytoskeletal crosstalkfilament dynamics and organelle positioningintracellular transportVimentin intermediate filaments

Identifiers

PMID41834240
PMCPMC12989643

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.