Evidence map›Paper›PMID 41834134›Full record

ArticleThe journals of gerontology. Series B, Psychological sciences and social sciences2026

Multistep inference across the human lifespan can be improved with individualized memory interventions.

Sharon M Noh, Keiland W Cooper, Shuheng Guo, Dale Zhou, Craig E L Stark, Aaron M Bornstein

Abstract read
In one paragraph

Article in The journals of gerontology. Series B, Psychological sciences and social sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. General knowledge and detailed memory benefit from different training sequences.Journal of applied research in memory and cognition · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sharon M NohDepartment of Cognitive Sciences, The University of California, Irvine, Irvine, California, United States.ORCID 0000-0003-0002-7759
Keiland W CooperDepartment of Neurobiology and Behavior, The University of California, Irvine, Irvine, California, United States.ORCID 0000-0002-0358-9645
Shuheng GuoDepartment of Cognitive Sciences, The University of California, Irvine, Irvine, California, United States.
Dale ZhouDepartment of Cognitive Sciences, The University of California, Irvine, Irvine, California, United States.ORCID 0000-0001-9240-1327
Craig E L StarkDepartment of Neurobiology and Behavior, The University of California, Irvine, Irvine, California, United States.ORCID 0000-0002-9334-8502
Aaron M BornsteinDepartment of Cognitive Sciences, The University of California, Irvine, Irvine, California, United States.ORCID 0000-0001-6251-6000

Funding

The Alzheimer's Disease Research Center at the University of California, IrvineP30AG066519 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Crystal M. Glover · 2020 to 2026
$27.9M
Development of the mnemonic similarity task as a tool to address age and dementia-related memory declineR01AG066683 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI STARK, CRAIG E · 2020 to 2024
$1.9M
Memory guided planning across the lifespanR01AG088306 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Ilana Jacqueline Bennett, Aaron Michael Bornstein · 2025 to 2026
$1.5M
Improving multi-step planning in aging by overcoming deficits in memory encodingR21AG072673 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI BORNSTEIN, AARON MICHAEL · 2021 to 2022
$801k
Age-related changes in memory alter decision-makingF32AG072836 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI NOH, SHARON M · 2022 to 2024
$221k
National Institute of Aging at the National Institutes of Health F32AG072836National Institute of Aging at the National Institutes of Health P30AG066519National Institute of Aging at the National Institutes of Health R01AG066683National Institute of Aging at the National Institutes of Health R01AG088306National Institute of Aging at the National Institutes of Health R21AG072673National Science Foundation DGE-1839285NIA NIH HHS F32 AG072836NIA NIH HHS P30 AG066519NIA NIH HHS R01 AG066683NIA NIH HHS R01 AG088306NIA NIH HHS R21 AG072673
6 · The paper itself

Abstract

objectivesEffective goal-directed decision making relies on memory and planning-processes that are known to decline with age. We tested the hypothesis that these declines stem from a common mechanism by focusing on mnemonic discrimination, a measure of memory precision that shows unique vulnerability to age-related decline.

methodsWe used a latent learning task that measures the ability to learn and make judgments about associations among interconnected stimuli, assessing performance across the adult life span. This task allows us to measure multistep inference judgments that reflect how individuals organize relational structure, previously shown to capture the internal model-construction processes that support model-based planning. In Experiment 1, we examined relationships between judgment performance and memory precision. In Experiment 2, we tested whether a "blocked" learning schedule designed to reduce memory interference by separating overlapping objects could improve performance for individuals with weaker memory abilities.

resultsAcross the life span, both younger and older adults showed evidence of successful latent learning and inference, but variability in judgment performance was explained by mnemonic discrimination ability. In Experiment 2, mnemonic discrimination interacted with training condition: intermixed training benefited those with high memory precision, whereas blocked training benefited those with low memory precision. We also implemented artificial neural network simulations, which reproduced these qualitative patterns. DISCUSSION: These findings suggest that age-related declines in complex judgments stem from declines in mnemonic discrimination and demonstrate that individualized, memory-based training interventions can improve learning and reasoning processes that support goal-directed planning, offering a promising approach to preserving decision-making abilities across the life span.

Indexed as

AgingDecision MakingJudgmentMemoryAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedYoung AdultGoal-directed planningIndividual differencesLatent learningMemory precisionTraining intervention

Identifiers

PMID41834134
PMCPMC13099142

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.