Evidence map›Paper›PMID 41834107›Full record

ArticleRheumatology (Oxford, England)2026

Time and patient journey to axial spondyloarthritis diagnosis: a retrospective study in French primary care.

Clément Prati, Arnaud Constantin, Emmanuelle Dernis, Jacques Eric Gottenberg, Marc Rozenblat, Elise Arnee, Marie Ducros, Cheikh Tamberou, Anneleen Vyncke, Julie Gandrup Horan

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Article in Rheumatology (Oxford, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Clément PratiDepartment of Rheumatology, Besancon University Hospital, Besancon, France.
Arnaud ConstantinRheumatology, Purpan Hospital and Paul Sabatier Toulouse III University, Toulouse, France.
Emmanuelle DernisDepartment of Rheumatology, Caen University Hospital, Caen, France.
Jacques Eric GottenbergRheumatology Department, Hôpitaux Universitaires de Strasbourg, Université de Strasbourg, Strasbourg, France.
Marc RozenblatCentre Coralis, Ozoir La Ferriere, France.
Elise ArneeGERS DATA, Patient Data France, Boulogne-Billancourt, France.
Marie DucrosGERS DATA, Patient Data France, Boulogne-Billancourt, France.
Cheikh TamberouGERS DATA, Patient Data France, Boulogne-Billancourt, France.
Anneleen VynckeUCB, Colombes, France.
Julie Gandrup HoranUCB, Slough, UK.

Funding

Chloe FouldsCostello MedicalMBiolUCBUCB in accordance with Good Publication Practice (GPP 2022)
6 · The paper itself

Abstract

objectivesAxial spondyloarthritis (axSpA) diagnoses are often delayed, which is associated with poorer patient outcomes. To improve understanding of diagnostic delay in France, we describe the time and patient journey to axSpA diagnosis in primary care.

methodsThis retrospective consecutive case series of adult axSpA patients in France (January 2000-August 2023) analysed primary care data from The Health Improvement Network® (THIN) database. Key study outcomes were time from earliest GP-recorded back pain diagnosis to axSpA diagnosis, and number and type of back pain episodes in this period. Other variables included axSpA symptoms and comorbidities at back pain and axSpA diagnosis, and healthcare resource utilization (HCRU).

resultsOf 7313 adult patients diagnosed with axSpA eligible for inclusion, 4402 had a prior back pain diagnosis. Mean time from earliest back pain to axSpA diagnosis was 6.3 years. Mean number of back pain episodes recorded prior to axSpA diagnosis was 6.1; 17.3% of patients experienced ≥10 episodes. Lower back pain was the most common (47.4% of diagnoses). The proportion of patients experiencing >1 axSpA symptom or comorbidity increased from 1.9% or 23.7% at earliest back pain diagnosis to 8.9% or 50.7% at axSpA diagnosis, respectively. HCRU was high; mean number of primary care consultations per patient per year between earliest back pain and axSpA diagnosis was 7.0.

conclusionsPatients in France wait over 6 years for an axSpA diagnosis. This research may raise awareness of the patient journey to axSpA diagnosis and support development of a primary care flagging strategy to identify patients with suspected axSpA earlier.

Indexed as

Axial SpondyloarthritisDelayed DiagnosisPrimary Health CareAdultBack PainFemaleFranceHumansMaleMiddle AgedPatient Acceptance of Health CareRetrospective StudiesTime FactorsTreatment Delaydelivery of health careobservational studiesprimary care rheumatologyroutinely collected dataspondyloarthritis

Identifiers

PMID41834107
PMCPMC13017005

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