Evidence map›Paper›PMID 41834095›Full record

ArticleMovement disorders clinical practice2026

Closing the Gate Before the Horse is out of the Barn: A Model to Effectively Predict the First Fall in Patients with Parkinson's Disease.

Saar Anis, Eric Zimmerman, Maxime Munyeshyaka, Hubert H Fernandez, Anson B Rosenfeldt, Jay L Alberts

Abstract read
In one paragraph

Article in Movement disorders clinical practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Saar AnisCenter for Neurological Restoration, Cleveland Clinic, Cleveland, Ohio, USA.
Eric ZimmermanCenter for Neurological Restoration, Cleveland Clinic, Cleveland, Ohio, USA.
Maxime MunyeshyakaCleveland Clinic Lerner College of Medicine, Cleveland Clinic, Cleveland, Ohio, USA.
Hubert H FernandezCenter for Neurological Restoration, Cleveland Clinic, Cleveland, Ohio, USA.
Anson B RosenfeldtDepartment of Biomedical Engineering, Cleveland Clinic, Cleveland, Ohio, USA.
Jay L AlbertsCenter for Neurological Restoration, Cleveland Clinic, Cleveland, Ohio, USA.

Funding

The Cyclical Lower-extremity Exercise for Parkinson's TrialR01NS073717 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI ALBERTS, JAY L. · 2011 to 2023
$4.8M
Edward and Barbara Bell Family Endowed ChairNational Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), USA 2R01NS073717NINDS NIH HHS R01 NS073717The Farmer Family Foundation
6 · The paper itself

Abstract

backgroundMost fall-prediction models in Parkinson's disease (PD) rely on prior falls, limiting prevention. The Waiting Room of the Future (WROTF) platform collects standardized motor and cognitive measures during routine visits, integrated into electronic health records (EHR).

objectiveTo develop a first-fall prediction model combining WROTF-EHR data and compare its performance with established cognitive- and motor-based models.

methodsPreviously published motor (Paul) and cognitive (CYCLE-II) models were refit using logistic regression. A new regularized (LASSO) model was developed. All models were evaluated using all participants and only those without prior falls.

resultsAmong 997 PD patients (mean age 69.6 ± 8.8; 62.8% male; disease duration 3.6 ± 4.3 years), AUCs were 0.77 (Paul), 0.70 (CYCLE-II), and 0.81 (LASSO). In fall-naïve patients, AUCs were 0.62, 0.68, and 0.70. Key predictors included processing speed, walking speed, disease duration, and age.

conclusionsThe model enables early fall-risk detection using routinely collected data, supporting proactive and personalized preventive care.

Indexed as

Accidental FallsParkinson DiseaseAgedElectronic Health RecordsFemaleHumansMalePrediction AlgorithmsPredictive Learning Modelsaccidental fallsParkinson's diseasereal‐world datarisk prediction

Identifiers

PMID41834095
PMCPMC13339295

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.