Evidence map›Paper›PMID 41834042›Full record

ReviewStem cell research & therapy2026

Intervertebral disc progenitor cells: roles in regeneration and disease.

Pulin Yan, Jian He, Yongwei Huang, Chen Lin, Sha Huang, Ou Hu, Peng Lin, Yingbo Wang, Huaijian Jin, Yangyang Li and 9 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Stem cell research & therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Pulin Yan *Department of Spine Surgery, Center of Orthopedics, State Key Laboratory of Trauma and Chemical Poisoning, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Jian He *Department of Spine Surgery, Center of Orthopedics, State Key Laboratory of Trauma and Chemical Poisoning, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Yongwei HuangBishan Hospital, Chongqing University of Chinese Medicine, Chongqing, 402760, China.
Chen LinBishan Hospital, Chongqing University of Chinese Medicine, Chongqing, 402760, China.
Sha HuangDepartment of Spine Surgery, Center of Orthopedics, State Key Laboratory of Trauma and Chemical Poisoning, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Ou HuDepartment of Spine Surgery, Center of Orthopedics, State Key Laboratory of Trauma and Chemical Poisoning, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Peng LinDepartment of Spine Surgery, Center of Orthopedics, State Key Laboratory of Trauma and Chemical Poisoning, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Yingbo WangDepartment of Spine Surgery, Center of Orthopedics, State Key Laboratory of Trauma and Chemical Poisoning, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Huaijian JinDepartment of Spine Surgery, Center of Orthopedics, State Key Laboratory of Trauma and Chemical Poisoning, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Yangyang LiDepartment of Spine Surgery, Center of Orthopedics, State Key Laboratory of Trauma and Chemical Poisoning, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Qin QinDepartment of Painology, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Yutong WuDepartment of Spine Surgery, Center of Orthopedics, State Key Laboratory of Trauma and Chemical Poisoning, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Jian WuDepartment of Spine Surgery, Center of Orthopedics, State Key Laboratory of Trauma and Chemical Poisoning, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Jungang PuDepartment of Spine Surgery, Center of Orthopedics, State Key Laboratory of Trauma and Chemical Poisoning, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Yangli XieCenter of Bone Metabolism and Repair, State Key Laboratory of Trauma and Chemical Poisoning, Trauma Center, Research Institute of Surgery, Laboratory for the Prevention and Rehabilitation of Military Training Related Injuries, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Lin ChenCenter of Bone Metabolism and Repair, State Key Laboratory of Trauma and Chemical Poisoning, Trauma Center, Research Institute of Surgery, Laboratory for the Prevention and Rehabilitation of Military Training Related Injuries, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Sien LinMusculoskeletal Research Laboratory, Department of Orthopedics & Traumatology, Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, 999077, Hong Kong SAR, China. sienlin@hku.hk.ORCID 0000-0002-7292-7062
Yibo GanDepartment of Spine Surgery, Center of Orthopedics, State Key Laboratory of Trauma and Chemical Poisoning, Daping Hospital, Army Medical University, Chongqing, 400042, China. ganyibo@tmmu.edu.cn.
Peng LiuDepartment of Spine Surgery, Center of Orthopedics, State Key Laboratory of Trauma and Chemical Poisoning, Daping Hospital, Army Medical University, Chongqing, 400042, China. liupengd@tmmu.edu.cn.

Funding

Chongqing High-end Medical Talents for Middle-aged and Young YXGD202408Health Medical Collaborative Innovation Program of Guangzhou 2023XJS39National Key Research and Development Program of China 2022YFA1103202National Natural Science Foundation of China 32200654National Natural Science Foundation of China 32270887National Natural Science Foundation of China 82272507National Natural Science Foundation of China 82430079National Natural Science Foundation of China 82472519Natural Science Foundation of Tianjin Municipal Science and Technology Commission CSTB2023NSCQ ZDJO008Open Project of State Key Laboratory of Trauma, Burns and Combined Injury SFLKF202201Research Grant Council of Hong Kong 14113723Research Grant Council of Hong Kong 14119124Research Grant Council of Hong Kong AE/M-402/20Research Grant Council of Hong Kong N_CUHK472/22Research Grant Council of Hong Kong T13-402/17-NTalent Innovation Training Program at the Army Medical Center ZXZYTSYS09
6 · The paper itself

Abstract

Intervertebral disc (IVD) degenerative disease is a prevalent and debilitating spinal disease. Current treatments only focus on symptomatic relief but fail to halt disease progression or restore the native biomechanical function of the spine. Regenerative medicine strategies, particularly those harnessing endogenous progenitor cells, offer a promising avenue for achieving biological repair and functional homeostasis. The identification of intervertebral disc progenitor cells (IVD-PCs) has unveiled a potential cellular reservoir for self-repair, given their demonstrated stemness attributes, including clonogenicity and multipotent differentiation. However, the clinical translation of IVD-PCs is significantly hampered by an incomplete understanding of their inherent heterogeneity, hierarchical organization, and, most critically, the dynamic interplay with their unique microenvironment, which dictates their fate decisions. This review synthesizes recent advances in deciphering the molecular signatures and functional plasticity of IVD-PCs. We place a particular emphasis on how key physicochemical, mechanical, and cellular cues within the IVD niche orchestrate progenitor cell behavior-ranging from maintenance and activation to aberrant differentiation-during both homeostasis and degeneration. Furthermore, we propose forward-looking insights to bridge critical knowledge gaps, aiming to propel the development of novel progenitor cell-based therapeutics for IVD degeneration.

Indexed as

Intervertebral DiscIntervertebral Disc DegenerationRegenerationStem CellsAnimalsCell DifferentiationHumansCell fateDegenerative disc diseaseMicroenvironmentProgenitor cell

Identifiers

PMID41834042
PMCPMC13112927

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.