Evidence map›Paper›PMID 41834039›Full record

ArticleBiology of sex differences2026

Social defeat stress responses in the stress alternative model are dependent on sex and anterior basolateral amygdala orexin 2 receptors.

Jazmine D W Yaeger, Megan M John, Leighton J Ledesma, Trent L Greschke, J J Gale, Lauren S Meyer, Renée A Brummels, Wayne J Korzan, R Parrish Waters, Cliff H Summers

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In one paragraph

Article in Biology of sex differences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Jazmine D W YaegerPediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD, 57104, USA.
Megan M JohnDepartment of Biology, University of South Dakota, 414 East Clark Street, Vermillion, SD, 57069-2390, USA.
Leighton J LedesmaIDP in Biomedical Sciences, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.
Trent L GreschkeDepartment of Biology, University of South Dakota, 414 East Clark Street, Vermillion, SD, 57069-2390, USA.
J J GaleDepartment of Biology, University of South Dakota, 414 East Clark Street, Vermillion, SD, 57069-2390, USA.
Lauren S MeyerDepartment of Biology, University of South Dakota, 414 East Clark Street, Vermillion, SD, 57069-2390, USA.
Renée A BrummelsDepartment of Biology, University of South Dakota, 414 East Clark Street, Vermillion, SD, 57069-2390, USA.
Wayne J KorzanDepartment of Biological and Environmental Sciences, The University of West Alabama, Livingston, AL, 34570, USA.
R Parrish WatersDepartment of Biological Sciences, University of Mary Washington, Fredericksburg, VA, 22401, USA.
Cliff H SummersDepartment of Biology, University of South Dakota, 414 East Clark Street, Vermillion, SD, 57069-2390, USA. cliff@usd.edu.

Funding

Sex Differences in the Neurobiological Significance of Orexin Stress SignalingR15MH125306 · NIMH · UNIVERSITY OF SOUTH DAKOTA · PI SUMMERS, CLIFF H · 2021 to 2021
$427k
National Science Foundation Graduate Research Fellowship Program DGE-1633213NIMH NIH HHS R15 MH125306
6 · The paper itself

Abstract

backgroundComprehending sex differences in stress vulnerability and the associated neurocircuitry has been elusive until the development of a method for investigating social defeat in female mice.

methodsThe Stress Alternatives Model (SAM) uses conditioning-induced agonistic behavior from novel male aggressors to separate distinct phenotypes characterized by stress-resilient active avoidance (Escape) or vulnerability (no Escape = Stay).

resultsUnlike males, females predominantly display Escape behavior, which is reversible (to Stay) by adding more social stress to behavioral environments. Despite this, females exhibit both stress-resilient and vulnerable phenotypic segregation. Stress-vulnerable females exhibit double conditioning-induced corticosterone secretion, more contextual fear conditioning, and reduced social preference. Systemic and intra-BLA injections of Orx

conclusionsFemale and male mice exposed to social stress exhibit distinct behavioral adaptations, but similarly, separate into resilient and susceptible subpopulations. Inhibiting Orx

Indexed as

Basolateral Nuclear ComplexOrexin ReceptorsSex CharacteristicsSocial DefeatStress, PsychologicalAnimalsAvoidance LearningCorticosteroneEscape ReactionFearFemaleMaleMiceMice, Inbred C57BLCorticosteroneOrexin ReceptorsAggressionAnxiousOrexin 2 receptorPhenotypeYohimbineα2 receptor

Identifiers

PMID41834039
PMCPMC13104226

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.