Evidence map›Paper›PMID 41833871›Full record

ArticleEnvironmental research2026

Maternal serum concentrations of persistent organic pollutants and childhood acute lymphoblastic leukemia in the Finnish Maternity Cohort.

Mary H Ward, Jessica M Madrigal, Rebecca Troisi, Heljä-Marja Surcel, Hanna Öhman, Juha Kivelä, Hannu Kiviranta, Panu Rantakokko, Jani Koponen, Danielle N Medgyesi and 4 more

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Article in Environmental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Mary H WardOccupational & Environmental Epidemiology Branch, Division of Cancer Epidemiology & Genetics (DCEG), National Cancer Institute (NCI), Rockville, Maryland, USA. Electronic address: wardm@mail.nih.gov.
Jessica M MadrigalOccupational & Environmental Epidemiology Branch, Division of Cancer Epidemiology & Genetics (DCEG), National Cancer Institute (NCI), Rockville, Maryland, USA.
Rebecca TroisiTrans-divisional Research Program, DCEG, NCI, USA.
Heljä-Marja SurcelBiobank Borealis of Northern Finland/Oulu University Hospital, Oulu, Finland; Faculty of Medicine, University of Oulu, Oulu, Finland.
Hanna ÖhmanBiobank Borealis of Northern Finland/Oulu University Hospital, Oulu, Finland; Faculty of Medicine, University of Oulu, Oulu, Finland.
Juha KiveläBiobank Borealis of Northern Finland/Oulu University Hospital, Oulu, Finland.
Hannu KivirantaFinnish Institute for Health and Welfare /Lifestyles and Living Environments Unit, Helsinki, Finland.
Panu RantakokkoFinnish Institute for Health and Welfare /Lifestyles and Living Environments Unit, Helsinki, Finland.
Jani KoponenFinnish Institute for Health and Welfare /Lifestyles and Living Environments Unit, Helsinki, Finland.
Danielle N MedgyesiOccupational & Environmental Epidemiology Branch, Division of Cancer Epidemiology & Genetics (DCEG), National Cancer Institute (NCI), Rockville, Maryland, USA; Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA.
Katherine A McGlynnMetabolic Epidemiology Branch, DCEG, NCI, USA.
Alexander P KeilOccupational & Environmental Epidemiology Branch, Division of Cancer Epidemiology & Genetics (DCEG), National Cancer Institute (NCI), Rockville, Maryland, USA.
Paul S AlbertBiostatistics Branch, DCEG, NCI, USA.
Rena R JonesOccupational & Environmental Epidemiology Branch, Division of Cancer Epidemiology & Genetics (DCEG), National Cancer Institute (NCI), Rockville, Maryland, USA.

Funding

Cancer Risk and Environmental ExposuresZIACP010125 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI PURDUE, MARK · 2009 to 2025
$41.3M
Intramural NIH HHS ZIA CP010125
6 · The paper itself

Abstract

BACKGROUND/

aimsChildren are exposed to persistent organic pollutants (POPs) including polychlorinated biphenyls (PCBs) and organochlorine pesticides through in utero transfer from maternal serum. Few studies have evaluated the relationship between POPs and childhood leukemia risk.

methodsThe Finnish Maternity Cohort is a population-based pregnancy cohort with banked serum and linkages to cancer registry and other databases. We measured first-trimester levels of 25 POPs in maternal sera collected in 1986-2010 for 388 childhood acute lymphoblastic leukemia (ALL) cases (<15 years) and 388 controls matched on sample date, gestational age (≥37 weeks; ± 1 week), birth order (first/second), mother's age, and child's sex. We analyzed lipid-adjusted POPs as continuous (log

resultsPOPs detected in >80% of controls included trans-nonachlor (93%), p',p'-dichlorodiphenylethylene (p',p'-DDE; 100%), hexachlorobenzene (99%), β-hexachlorocyclohexane (β-HCH; 84%), and 10 PCBs (range: 84-100%). Increasing trans-nonachlor concentrations were associated with ALL (adjusted OR

conclusionOur findings suggest that trans-nonachlor and some PCBs may increase childhood leukemia risk with unexplained inverse associations for β-HCH and p',p'-DDE.

Indexed as

Maternal ExposurePersistent Organic PollutantsPrecursor Cell Lymphoblastic Leukemia-LymphomaPrenatal Exposure Delayed EffectsAdolescentAdultCase-Control StudiesChildChild, PreschoolCohort StudiesFemaleFinlandHumansHydrocarbons, ChlorinatedInfantMaleHydrocarbons, ChlorinatedPersistent Organic PollutantsPesticidesPolychlorinated BiphenylsAcute lymphoblastic leukemiaChildhood leukemiaChlordaneDichlorodiphenyltrichloroethaneOrganochlorine pesticidesPolybrominated diphenyl ethersPolychlorinated biphenyls

Identifiers

PMID41833871
PMCPMC13157125

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.