Evidence map›Paper›PMID 41833783›Full record

ArticlePhysiology & behavior2026

Increased alcohol drinking and seizure susceptibility in female humanized ApoE4 knockin rats.

Chan Young Choi, Jassmyn J Venegas, Sarah M Rauch, Francis A Walter, Joel N Ryan, Mythili Machireddy, Jacob M Weisz, Gregory C Tracy, Annie J Baker, Stan B Floresco and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiology & behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Chan Young ChoiDepartment of Psychology, University of Illinois Urbana Champaign, USA.
Jassmyn J VenegasDepartment of Psychology, University of Illinois Urbana Champaign, USA.
Sarah M RauchDepartment of Psychology, University of Illinois Urbana Champaign, USA.
Francis A WalterNeuroscience Program, University of Illinois Urbana Champaign, USA.
Joel N RyanSchool of Molecular and Cellular Biology, University of Illinois Urbana Champaign, USA.
Mythili MachireddySchool of Molecular and Cellular Biology, University of Illinois Urbana Champaign, USA.
Jacob M WeiszDepartment of Psychology, University of Illinois Urbana Champaign, USA.
Gregory C TracyDepartment of Molecular and Integrative Physiology, University of Illinois Urbana Champaign, USA.
Annie J BakerDepartment of Molecular and Integrative Physiology, University of Illinois Urbana Champaign, USA.
Stan B FlorescoDepartment of Psychology, University of British Columbia, Canada.
Hee Jung ChungDepartment of Molecular and Integrative Physiology, University of Illinois Urbana Champaign, USA.
Nu-Chu LiangDepartment of Psychology, University of Illinois Urbana Champaign, USA. Electronic address: ncliang8@illinois.edu.

Funding

Super-Resolution Microscopy of Neuronal Synapses with Small Quantum Dots and Advanced Imaging ToolsR01NS100019 · NINDS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI CHUNG, HEE JUNG, SELVIN, PAUL R · 2017 to 2025
$3.2M
Super-Resolution Fluorescence Microscopy of Synaptic Plasticity on Unmodified Brain Slices in Health and TauopathyRF1AG083625 · NIA · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI CHUNG, HEE JUNG, SELVIN, PAUL R · 2023 to 2023
$1.9M
NIA NIH HHS RF1 AG083625NINDS NIH HHS R01 NS100019
6 · The paper itself

Abstract

Epidemiological analyses suggest that the Ɛ4 allele of apolipoprotein E (ApoE) genes may influence the effects of alcohol on cognitive and executive function and dementia risk compared to the Ɛ3 allele. Here, we investigated this question in female rats given that women are more vulnerable than men to the Ɛ4 genotype effects on various diseases. Experiment 1 examined the effects of alcohol drinking on performance in a Barnes maze and an operant strategy set-shifting (OSS) task during abstinence in wildtype (WT) and homozygous ApoE4 knock-in (E4) rats. Experiment 2 repeated the behavioral assessments to assess the effects of heavy alcohol exposure and explored seizure susceptibility in E4 and homozygous ApoE3 knock-in (E3) rats. The experiments revealed that E4 rats drank significantly higher doses of alcohol than did the WT and E3 rats. However, there was no genotype or alcohol effect on performance in the Barnes maze and the OSS task. Notably, E4 rats had a shorter latency to kainate-induced seizures and maintained worse seizures compared to age-matched E3 rats. These findings suggest that the Ɛ4 allele may confer a higher risk for increased alcohol drinking without significantly exacerbating alcohol-associated decline in cognitive and executive function in females. Given the scarcity and discrepant reports regarding the role of ApoE polymorphism on seizure disorders among human and rodent studies, results of this study also underscore the need for more rigorous clinical and preclinical studies to determine the role of ApoE in sporadic and alcohol withdrawal seizures.

Indexed as

Alcohol DrinkingApolipoprotein E4SeizuresAnimalsApolipoprotein E3Conditioning, OperantDisease Models, AnimalEthanolExecutive FunctionFemaleGene Knock-In TechniquesGenetic Predisposition to DiseaseHumansKainic AcidMaze LearningRatsApolipoprotein E3Apolipoprotein E4EthanolKainic AcidAlcoholApoEBarnes mazeExecutive functionGene-environment interactionSeizureStrategy set-shifting

Identifiers

PMID41833783
PMCPMC13123892

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.