Evidence map›Paper›PMID 41833734›Full record

ArticleThe Journal of biological chemistry2026

The crystal structure of the herpes virus ICP8 protein in complex with single-stranded DNA reveals the molecular determinants of nucleotide recognition.

Heidi Erlandsen, Jolanta Krucinska, P Ross Wilderman, Andrea M Makkay, Renata Szczepaniak, Lee R Wright, Sandra K Weller, Dennis L Wright

Abstract read
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In one paragraph

Article in The Journal of biological chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Heidi ErlandsenDepartment of Pharmaceutical Sciences, University of Connecticut School of Pharmacy, Storrs, Connecticut, USA.
Jolanta KrucinskaDepartment of Pharmaceutical Sciences, University of Connecticut School of Pharmacy, Storrs, Connecticut, USA.
P Ross WildermanDepartment of Molecular Biology and Biophysics, University of Connecticut School of Medicine, Farmington, Connecticut, USA.
Andrea M MakkayDepartment of Molecular Biology and Biophysics, University of Connecticut School of Medicine, Farmington, Connecticut, USA.
Renata SzczepaniakDepartment of Molecular Biology and Biophysics, University of Connecticut School of Medicine, Farmington, Connecticut, USA.
Lee R WrightDepartment of Pharmaceutical Sciences, University of Connecticut School of Pharmacy, Storrs, Connecticut, USA.
Sandra K WellerDepartment of Molecular Biology and Biophysics, University of Connecticut School of Medicine, Farmington, Connecticut, USA. Electronic address: Weller@UCHC.edu.
Dennis L WrightDepartment of Pharmaceutical Sciences, University of Connecticut School of Pharmacy, Storrs, Connecticut, USA. Electronic address: Dennis.Wright@UConn.edu.

Funding

GENETICS OF HSV DNA REPLICATIONR01AI021747 · NIAID · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI WELLER, SANDRA K, WRIGHT, DENNIS L. · 1985 to 2024
$9.9M
NIAID NIH HHS R01 AI021747
6 · The paper itself

Abstract

The HSV-1 single-strand annealing protein ICP8 (UL29) is essential for viral DNA replication and recombination. Although its overall architecture has been described, the molecular basis of single-stranded DNA (ssDNA) recognition was unknown. We report crystal structures of C-terminally truncated ICP8 (ICP8Δ60) bound to poly(dT)

Indexed as

DNA-Binding ProteinsDNA, Single-StrandedHerpesvirus 1, HumanNucleotidesViral ProteinsCrystallography, X-RayModels, MolecularProtein ConformationDNA-Binding ProteinsDNA, Single-StrandedICP8 protein, SimplexvirusNucleotidesViral Proteinsherpesvirus replicationHSV ICP8HSV UL29human herpesvirussingle-strand annealing proteinssingle-strand DNA binding proteinsX-ray crystallography

Identifiers

PMID41833734
PMCPMC13137030

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.