Evidence map›Paper›PMID 41833640›Full record

ArticleKidney international2026

The role of C-C motif chemokine ligand 2 in the preservation of myogenic tone in the kidney microvasculature of Dahl Salt-Sensitive rats.

Wenguang Feng, Zhengrong Guan, Wei-Zhong Ying, Conrad Feng, Kelly A Hyndman, Paul W Sanders

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wenguang FengDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Zhengrong GuanDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Wei-Zhong YingDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Conrad FengDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Kelly A HyndmanDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA; Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Paul W SandersDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA; Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA; Birmingham Veterans Affairs Health Care System, Birmingham, Alabama, USA. Electronic address: psanders@uab.edu.

Funding

UAB-UCSD O'Brien Core Center for Acute Kidney Injury ResearchP30DK079337 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AGARWAL, ANUPAM · 2008 to 2022
$18.3M
UAB-UCSD O'Brien Center for Acute Kidney Injury ResearchU54DK137307 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI PAUL W. SANDERS · 2023 to 2026
$4.4M
Epigenetic Regulation of Kidney Fibrosis following AKIR01DK126664 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI HYNDMAN, KELLY · 2021 to 2024
$1.7M
BLRD VA I01 BX005640NIDDK NIH HHS P30 DK079337NIDDK NIH HHS R01 DK126664NIDDK NIH HHS U54 DK137307
6 · The paper itself

Abstract

introductionMechanisms of kidney injury in hypertension are incompletely understood. Here, we investigate the role of C-C motif chemokine ligand 2 (CCL2) in kidney microvascular function and hypertension-associated kidney injury using male Dahl salt-sensitive (SS) rats and SS rats lacking Ccl2 (SS

methodsSS and SS

resultsSS, but not SS

conclusionsCCL2 directly impairs kidney microvascular smooth muscle contractility, leading to autoregulatory dysfunction and kidney injury in hypertensive SS rats. The findings highlight CCL2 as a potential therapeutic target in hypertensive nephropathy.

Indexed as

Chemokine CCL2HypertensionKidneyMicrovesselsAnimalsBlood PressureDisease Models, AnimalMaleMuscle, Smooth, VascularMyosin-Light-Chain KinaseMyosin Light ChainsRatsRats, Inbred DahlSodium Chloride, DietaryVasoconstrictionCcl2 protein, ratChemokine CCL2Myosin-Light-Chain KinaseMyosin Light ChainsSodium Chloride, Dietaryafferent arteriolar autoregulationchemokinesDahl salt-sensitive rathypertensionhypertension-associated nephropathy

Identifiers

PMID41833640
PMCPMC13138133

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.