ArticleAnti-cancer agents in medicinal chemistry2026
Apoptotic and Anti-Proliferative Potential of
Article in Anti-cancer agents in medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionAlgae have garnered increasing interest in the fields of medicine and nutrition as a source of nutritious and non-toxic healthcare supplements. Spirulina platensis (SP), a microalga and a welldocumented nutritional supplement, is recognized for its high medicinal value and potential anticancer properties. The present study evaluated the apoptosis-inducing effect of methanolic extract of Spirulina platensis (SPM) on human breast cancer MDA-MB-231 cells.
methodsThe extract was prepared using standard methanol extraction techniques. Cytotoxicity was assessed using the MTT assay over varying concentrations and time intervals. Morphological changes were observed under a phase-contrast microscope. Apoptosis was further confirmed through acridine orange/ ethidium bromide (AO/EB) dual staining and DNA fragmentation analysis. The effect of SPM on normal HEK-293 cells was also evaluated to determine its selectivity and safety profile.
resultsHPLC analysis identified C-phycocyanin (C-PC) as the major bioactive phytoconstituent in the SPM extract. The extract showed antioxidant activity and dose- and time-dependent growth inhibition of MDA-MB-231 cells (IC DISCUSSION: The presence of C-PC most likely contributes to the extract's antioxidant and anticancer effects. SPM selectively induced apoptosis and inhibited proliferation in MDA-MB-231 cells, with a negligible impact on normal cells, highlighting its potential as a safe and natural anticancer candidate.
conclusionAs evident from the results, SPM extract has demonstrated potential for its clinical applications in cancer therapy as an adjunct to the main line of treatment, provided that further studies are carried out on other cancer cell lines and animal models in future.
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