Evidence map›Paper›PMID 41833013›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

OsGSK2-OsTCP19 Module Integrates Nitrogen and Brassinosteroid Signaling to Regulate Nitrogen Utilization and Root Growth in Rice.

Yongqiang Liu, Weiwei Li, Xiaohui Ma, Xiaohan Wang, Yarong Shi, Xiahe Huang, Xinran Li, Yingchun Wang, Hongning Tong, Bin Hu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yongqiang LiuInstitute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.ORCID https://orcid.org/0000-0002-3138-7207
Weiwei LiKey Laboratory for Enhancing Resource Use Efficiency of Crops in South China, Ministry of Agriculture and Rural Affairs, South China Agricultural University, Guangzhou, China.
Xiaohui MaKey Laboratory of Plant Molecular Physiology, Institute of Botany, Chinese Academy of Sciences, Beijing, China.
Xiaohan WangInstitute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
Yarong ShiState Key Laboratory of Crop Gene Resources and Breeding, National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.
Xiahe HuangInstitute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
Xinran LiState Key Laboratory of Forage Breeding-by-Design and Utilization, Institute of Botany, Chinese Academy of Sciences, Beijing, China.
Yingchun WangInstitute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
Hongning TongState Key Laboratory of Crop Gene Resources and Breeding, National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.
Bin HuKey Laboratory for Enhancing Resource Use Efficiency of Crops in South China, Ministry of Agriculture and Rural Affairs, South China Agricultural University, Guangzhou, China.
Wenbin ZhouState Key Laboratory of Crop Gene Resources and Breeding, National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.ORCID https://orcid.org/0000-0001-5911-1686
Chengcai ChuInstitute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.ORCID https://orcid.org/0000-0001-8097-6115

Funding

Central Public-Interest Scientific Institution Basal Research Fund S2025PY04China National Postdoctoral Program for Innovative Talents BX2021352National Natural Science Foundation of China 32102477National Natural Science Foundation of China 32472156National Natural Science Foundation of China U23A20185Youth Innovation of Chinese Academy of Agricultural Sciences Y2026QC02
6 · The paper itself

Abstract

Nitrogen (N) and brassinosteroids (BRs) are key regulators of plant developmental plasticity in fluctuating nutrient environments, yet the direct molecular link coordinating these two signaling pathways remains elusive. Here, we report a synergistic interplay between nitrate and BR signaling that governs N utilization and lateral root development in rice (Oryza sativa L.). Nitrate activates BR response in a dose-dependent manner, with maximal induction at 2.5 mM nitrate. Conversely, activated BR signaling enhances nitrate signaling and lateral root elongation, which strictly depends on the protein level of OsTCP19, a negative regulator of root growth. Nitrate-induced BR signaling promotes OsTCP19 degradation within 2-4 h, while the BR signaling core kinase OsGSK2 interacts with and phosphorylates OsTCP19 at Ser141 and Thr289 to stabilize its protein. OsTCP19 directly binds to the promoters of nitrate-responsive genes (e.g., OsNRT2.4, OsNADH-GOGAT1, OsASN1) and root development genes (e.g., OsIAA3, OsPIN1b, OsARF19) to negatively regulate N responses and lateral root growth, respectively. Together, the OsGSK2-OsTCP19 module establishes a direct molecular link between nitrate and BR signaling, coordinating N utilization and root plasticity in rice.

Indexed as

BrassinosteroidsNitrogenOryzaPlant ProteinsPlant RootsSignal TransductionGene Expression Regulation, PlantNitratesBrassinosteroidsNitratesNitrogenPlant Proteins

Identifiers

PMID41833013
PMCPMC13248756

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.