ArticleJournal of surgical oncology2026
Analysis of the Relationship Between Survival and Postoperative Infection in Patients With Osteosarcoma.
Article in Journal of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Historical contributions and future horizons of Japanese orthopaedic oncology: from surgical innovation to nationwide collaborations.International orthopaedics · 2026Article
- Association between postoperative surgical site infection and oncologic outcomes in soft tissue sarcoma: a propensity score-matched analysis using the bone and soft tissue registry.International orthopaedics · 2026Article
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPostoperative infections remain a critical concern in the management of osteosarcoma, particularly after limb salvage surgery. While infections are often perceived as detrimental, emerging evidence suggests that under certain circumstances, localized infections may improve survival outcomes. This study evaluated the relationship between postoperative infection and survival in Japanese patients with osteosarcoma.
methodsWe retrospectively reviewed the medical records of patients diagnosed with osteosarcoma who underwent surgery between April 1990 and October 2021 at nine institutions. Patients with trunk or pelvic lesions, distant metastases at initial diagnosis, age over 60, or infections occurring more than 1 year postoperatively were excluded.
resultsAmong 466 eligible patients, 34 (7.3%) developed postoperative infections. The 5-year overall survival rate was 84.4% in infected patients and 82.9% in non-infected patients, with no significant difference (p = 0.778). The proximal tibia was more susceptible to infection than other sites, with an odds ratio of 2.621 (p = 0.008), and larger tumors were more likely to develop infection (odds ratio, 1.093; p = 0.009).
conclusionsPostoperative infection did not improve survival in patients with osteosarcoma. Tumors in the proximal tibia and those with larger maximum diameters were more susceptible to infection.
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