ReviewMini reviews in medicinal chemistry2026
Association of Metabolic Syndrome and Cholelithiasis: Understanding the Underlying Mechanism for Better Treatment.
Review in Mini reviews in medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metabolic syndrome is characterized by a combination of conditions, including abdominal obesity, elevated blood pressure, increased blood sugar levels, and high triglycerides. The incidence of metabolic syndrome is concerningly increasing worldwide. Metabolic syndrome increases the risk of cardiovascular diseases, type 2 diabetes mellitus, non-alcoholic fatty liver disease, chronic kidney disease, and even cancer. Cholelithiasis refers to the formation of gallstones. Metabolic associations, including dyslipidemia, obesity, diabetes, and insulin resistance, are all risk factors for cholelithiasis. Modifiable factors include changes in lifestyle and metabolic conditions. In this narrative review, we searched the PubMed, Scopus, and Google Scholar databases to identify evidence-based literature on the association between metabolic syndrome and cholelithiasis. We discuss the biochemical reaction underlying cholelithiasis, the receptors and signaling pathways involved, and therapeutic options targeting hepatic cholesterol synthesis and secretion. We discuss the molecular mechanisms underlying the association between metabolic syndrome and cholelithiasis, including insulin resistance, genetic factors, and gallbladder functions relevant to cholelithiasis. The clinical implications, along with surgical interventions and treatment, are also discussed in detail. The review may benefit physicians involved in the treatment of cholelithiasis and metabolic syndrome, and help researchers develop appropriate drugs in the future.
Indexed as
Identifiers
41832733What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.