ReviewCurrent medicinal chemistry2026
Natural Products as Anti-Senescence-Associated Secretory Phenotype (SASP) Agents.
Review in Current medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Mitochondrial homeostasis and aging: the mtDNA-cGAS-STING axis.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cellular senescence denotes an irreversible cell-cycle arrest implicated in organismal aging and age-related disorders, distinguished by the Senescence-Associated Secretory Phenotype (SASP). SASP manifests the capacity of senescent cells to secrete a broad array of bioactive molecules-cytokines, chemokines, proteases, growth factors, and bioactive lipids that orchestrate diverse extracellular functions across pathological contexts. Senomorphic strategies that selectively suppress SASP have emerged as promising therapeutic avenues for mitigating aging-related pathologies. Natural products, including polyphenols, flavonoids, and alkaloids, possess inherent antioxidant and anti-inflammatory properties and have demonstrated significant efficacy in modulating SASP in both aging and diseases. This review, for the first time, systematically consolidates current investigations into natural compounds targeting SASP, providing a comprehensive analysis of their underlying mechanisms, therapeutic potential, and prospects for clinical translation in non-cancerous age-related diseases. We delineate how SASP is initiated, its composition, pathophysiological roles, and how natural compounds modulate it, thereby establishing a foundation for future research and therapeutic development in ageing intervention.
Indexed as
Identifiers
41832707What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.