Evidence map›Paper›PMID 41832600›Full record

ArticleMolecular therapy : the journal of the American Society of Gene Therapy2026

Microglia-independent rAAV-induced inflammation causes persistent ocular immune dysregulation rescued by S1P receptor modulation.

Philip M Langer, Alison J Clare, Xudong Peng, Katherine L Costello, Suci Cendanawati, Leslie L Wilson, Amy Ward, Oliver H Bell, Colin J Chu, Ying Kai Chan and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Philip M LangerAcademic Unit of Ophthalmology, Bristol Medical School, University of Bristol, Bristol BS8 1TD, UK; Department of Ophthalmology, School of Medicine, University of Washington, Seattle, WA 98104, USA.
Alison J ClareAcademic Unit of Ophthalmology, Bristol Medical School, University of Bristol, Bristol BS8 1TD, UK; National Institute of Health Research (NIHR) Moorfields Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and University College London Institute of Ophthalmology, London EC1V 2PD, UK.
Xudong PengDepartment of Ophthalmology, School of Medicine, University of Washington, Seattle, WA 98104, USA.
Katherine L CostelloDepartment of Ophthalmology, School of Medicine, University of Washington, Seattle, WA 98104, USA.
Suci CendanawatiSchool of Cellular and Molecular Medicine, University of Bristol, Bristol BS8 1TD, UK.
Leslie L WilsonDepartment of Ophthalmology, School of Medicine, University of Washington, Seattle, WA 98104, USA.
Amy WardAcademic Unit of Ophthalmology, Bristol Medical School, University of Bristol, Bristol BS8 1TD, UK.
Oliver H BellAcademic Unit of Ophthalmology, Bristol Medical School, University of Bristol, Bristol BS8 1TD, UK.
Colin J ChuAcademic Unit of Ophthalmology, Bristol Medical School, University of Bristol, Bristol BS8 1TD, UK; Institute of Ophthalmology, University College London, London EC1V 9EL, UK; National Institute of Health Research (NIHR) Moorfields Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and University College London Institute of Ophthalmology, London EC1V 2PD, UK.
Ying Kai ChanAcademic Unit of Ophthalmology, Bristol Medical School, University of Bristol, Bristol BS8 1TD, UK; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02215, USA.
Andrew D DickAcademic Unit of Ophthalmology, Bristol Medical School, University of Bristol, Bristol BS8 1TD, UK; School of Cellular and Molecular Medicine, University of Bristol, Bristol BS8 1TD, UK; Institute of Ophthalmology, University College London, London EC1V 9EL, UK; National Institute of Health Research (NIHR) Moorfields Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and University College London Institute of Ophthalmology, London EC1V 2PD, UK.
Kathryn L PeppleDepartment of Ophthalmology, School of Medicine, University of Washington, Seattle, WA 98104, USA. Electronic address: kpepple@uw.edu.
David A CoplandAcademic Unit of Ophthalmology, Bristol Medical School, University of Bristol, Bristol BS8 1TD, UK; National Institute of Health Research (NIHR) Moorfields Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and University College London Institute of Ophthalmology, London EC1V 2PD, UK. Electronic address: dave.copland@bristol.ac.uk.

Funding

Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Sakeneh Zraika · 1986 to 2026
$41.4M
Vision Research CoreP30EY001730 · NEI · UNIVERSITY OF WASHINGTON · PI Jay Neitz · 1985 to 2026
$23.5M
Immune mechanisms of post-infectious uveitisR01EY030431 · NEI · UNIVERSITY OF WASHINGTON · PI PEPPLE, KATHRYN · 2019 to 2023
$2.2M
NEI NIH HHS P30 EY001730NEI NIH HHS R01 EY030431NIDDK NIH HHS P30 DK017047
6 · The paper itself

Abstract

Inflammation elicited by rAAV vectors continues to present a critical challenge for the long-term efficacy and safety of gene therapy in the eye. Preclinical models of gene therapy-associated uveitis (GTAU) show that despite the resolution of early acute inflammatory response, persistent subclinical inflammation remains. Here, we employ the GTAU model in Cx3cr1

Indexed as

DependovirusGenetic VectorsInflammationMicrogliaReceptors, LysosphingolipidUveitisAnimalsDisease Models, AnimalGene Therapy AgentsGenetic TherapyMiceT-LymphocytesReceptors, LysosphingolipidAAVadeno-associated viruseyegene therapyGTAUinflammationmicrogliaocularretinauveitisviral vector

Identifiers

PMID41832600
PMCPMC13154287

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.