ArticleCardiovascular diabetology2026
Association between C-reactive protein-triglyceride-glucose index and risk of stroke in different renal function status: a national cohort study.
Article in Cardiovascular diabetology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Associations between the C-reactive protein-triglyceride-glucose index and its derived indices and the incidence and progression of cardiometabolic multimorbidity in participants with metabolic dysfunction-associated steatotic liver disease: a large-scale prospective cohort study.Cardiovascular diabetology · 2026Article
- Association of the C-reactive protein-triglyceride glucose index with microvascular obstruction and long-term prognosis in patients with acute myocardial infarction: a CMR-based study.Frontiers in endocrinology · 2026Observational
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6 authors.
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Abstract
backgroundThe C-reactive protein-triglyceride-glucose index (CTI), a novel biomarker integrating inflammation and insulin resistance, has been linked to cardiovascular disease. However, its association with stroke risk across varying levels of renal function remains unclear.
methodsThis prospective cohort study included 8,808 participants aged ≥ 45 years from the China Health and Retirement Longitudinal Study (CHARLS), covering the period 2011 to 2018. CTI was calculated as 0.412×Ln (CRP [mg/L]) + Ln (TG [mg/dL]×FPG [mg/dL])/2. Multivariable Cox models and restricted cubic splines were employed to assess the association between CTI and incident stroke. We stratified the analysis by estimated glomerular filtration rate (eGFR) and introduced interaction terms between CTI and eGFR levels to evaluate potential effect modification.
resultsThe mean age of the participants was 59.48 (9.41) years, and 4098 (46.5%) were male. During a median follow-up of 7 years, 404 (4.6%) stroke events occurred. In the fully adjusted model, each 1-unit increase in CTI was associated with a 15% higher stroke risk [hazard ratios (HR) = 1.15, 95% confidence interval (CI) = 1.00-1.32]. A significant positive linear dose-response relationship was observed (P
conclusionElevated CTI levels are associated with an increased risk of stroke in middle-aged and older Chinese adults, particularly among individuals with mild renal impairment. By combining inflammatory and metabolic markers, CTI might offer potential clinical value for risk assessment.
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