Evidence map›Paper›PMID 41832464›Full record

ArticleBMC cancer2026

Association of MET gene polymorphisms with breast cancer risk in Nigerian patients: a case-control study.

Doris Nnenna Amuji, Emeka E J Iweala

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Doris Nnenna AmujiDepartment of Biochemistry, College of Science and Technology, Covenant University, KM 10, Canaan Land, Idiroko Road, Ota, Ogun State, Nigeria. doris.amujipgs@stu.cu.edu.ng.
Emeka E J IwealaDepartment of Biochemistry, College of Science and Technology, Covenant University, KM 10, Canaan Land, Idiroko Road, Ota, Ogun State, Nigeria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBreast cancer (BC) is a major cause of cancer-related mortality among women worldwide. Genetic polymorphisms, such as those in the Mesenchymal Epithelial Transition factor (MET) proto-oncogene, may influence cancer risk and progression. This study aimed to evaluate the association between previously reported single-nucleotide polymorphisms (SNPs) of the MET gene, rs40239, rs1621, and rs41736, and the risk of breast cancer in Nigerian patients.

methods75 samples of DNA from buffy coats of patients with breast cancer and 75 healthy controls were collected and genotyped for MET rs40239, rs1621, and rs41736 polymorphisms using the TaqMan SNP assay.

resultsOur study has shown that none of the examined SNPs of the MET gene was associated with risk of breast cancer (OR = 4.706, 95% CI: 0.959–23.096, p = 0.062 for rs40239; OR = 1.188, 95% CI: 0.516–2.733, p = 0.426 for rs1621; OR = 0.954, 95% CI: 0.904–1.006, p = 0.262 for rs41736).

conclusionOur findings suggest no statistically significant associations between the MET rs40239, rs1621, and rs41736 polymorphisms and breast cancer risk in the studied Nigerian population.

Indexed as

Breast NeoplasmsGenetic Predisposition to DiseasePolymorphism, Single NucleotideProto-Oncogene Proteins c-metAdultAgedCase-Control StudiesFemaleGenetic Association StudiesGenotypeHumansMiddle AgedNigeriaProto-Oncogene MasRisk FactorsMAS1 protein, humanMET protein, humanProto-Oncogene MasProto-Oncogene Proteins c-metBreast cancerGenotypeMET genePolymorphism

Identifiers

PMID41832464
PMCPMC13101176

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.