ArticleBMC gastroenterology2026
Beyond the bowel: novel comorbidity patterns in inflammatory bowel disease from the all of us research program.
Article in BMC gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Microbiota-derived metabolites and cardiovascular implications in Inflammatory Bowel Disease (IBD).Molecular medicine (Cambridge, Mass.) · 2026Review
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundInflammatory bowel disease (IBD) manifests systemically, yet most comorbidity studies rely on predominantly European populations. The All of Us Research Program enables investigation across demographically diverse groups.
methodsWe matched 5,094 IBD patients 1:4 with controls by age, gender, and race, analyzing comorbidities using logistic regression with Mantel–Haenszel adjustment. Multiple testing correction used false discovery rate (FDR) with significance thresholds of OR > 1.5 or < 0.5 and FDR < 0.05.
resultsOur cohort included 29.2% non-White participants versus 10–15% in traditional studies. We identified 22 significant associations across seven organ systems. Three novel discoveries included delayed postmyocardial infarction pericarditis (adjusted OR = 4.80), contact dermatitis (adjusted OR = 1.84), and carotid artery aneurysm (adjusted OR = 2.21). Other significant associations included drug-induced lupus (adjusted OR = 4.32), autoimmune hepatitis (adjusted OR = 2.43), and anorexia nervosa (adjusted OR = 2.29). IBD patients showed decreased obesity-related conditions.
conclusionThis demographically diverse study discovered novel IBD comorbidities and confirmed established associations across racial groups. Findings support conceptualizing IBD as a multisystem disorder requiring comprehensive management and demonstrate the importance of diverse research populations.
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