Evidence map›Paper›PMID 41832358›Full record

ArticleAnnals of surgical oncology2026

Multifactorial Impact of Age, Race, and Female Sex on Management of Non-small Cell Lung Cancer.

Anupama Singh, Yue Xie, Miles A McAllister, Emanuele Mazzola, Fatemehsadat Pezeshkian, Narjust Florez, Michael T Jaklitsch, Fatima G Wilder

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Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anupama SinghDivision of Thoracic and Cardiac Surgery, Brigham and Women's Hospital, Boston, MA, USA. anupamasingh0312@gmail.com.ORCID http://orcid.org/0000-0001-7776-4584
Yue XieDepartment of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA.
Miles A McAllisterDivision of Thoracic and Cardiac Surgery, Brigham and Women's Hospital, Boston, MA, USA.
Emanuele MazzolaDepartment of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA.
Fatemehsadat PezeshkianDivision of Thoracic and Cardiac Surgery, Brigham and Women's Hospital, Boston, MA, USA.
Narjust FlorezDivision of Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Michael T JaklitschDivision of Thoracic and Cardiac Surgery, Brigham and Women's Hospital, Boston, MA, USA.
Fatima G WilderDivision of Thoracic and Cardiac Surgery, Brigham and Women's Hospital, Boston, MA, USA.

Funding

Division of Cancer Prevention, National Cancer Institute U01CA202979
6 · The paper itself

Abstract

backgroundThe purpose of this study was to evaluate the impact of age and race on female patients with non-small cell lung cancer (NSCLC) and identify factors posing a greater risk to overall survival (OS). PATIENTS AND

methodsA retrospective analysis of the Southern Community Cohort Study database was conducted of female patients diagnosed with NSCLC from 2004 to 2018. Patients were stratified into Black versus white groups and by age: < 55 years and ≥ 55 years. Fisher's exact test was used to compare categorical variables and Wilcoxon rank sum for numerical variables. Hazard ratios were calculated to assess risk on OS for both races.

resultsBlack female patients, more often than white female patients, were diagnosed with pathologic stage IV (43.2% versus 33.9%, p = 0.02), did not receive lymphadenectomy (75.3% versus 64.8%, p = 0.02), and did not undergo surgery of the primary site (80.2% versus 65.4%, p = 0.002). Age-stratified analysis revealed more apparent trends for Black female patients. Compared with their older counterparts, younger Black female patients presented with larger tumor sizes (43.7 mm versus 40.2 mm), were more often diagnosed with clinical metastasis (11.6% versus 8.8%), and had higher rates of death due to their malignancy (74.0% versus 58.1%). Factors protective for OS were private insurance (HR 0.51 Black versus HR 0.34 white), number of persons in household (HR 0.78 Black versus HR 0.80 white). Urban environment was protective for Black female patients (HR 0.75) and rural environment for white female patients (HR 0.60).

conclusionsDisparities are prevalent in different groups of female patients with NSCLC. Continued work is imperative to improve care for this increasingly vulnerable demographic.

Indexed as

Black or African AmericanCarcinoma, Non-Small-Cell LungHealthcare DisparitiesLung NeoplasmsAgedAge FactorsFemaleFollow-Up StudiesHumansLymph Node ExcisionMiddle AgedPrognosisRetrospective StudiesSex FactorsSurvival RateWhiteAge disparitiesFemale sexMinority patientsNon-small cell lung cancerRace disparities

Identifiers

PMID41832358

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.