ArticleLung2026
Lung Volumes in Tobacco-Exposed Individuals with Preserved Spirometry: An Overlooked Pointer of Respiratory Health?
Article in Lung, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeSpirometry, the standard for diagnosing chronic obstructive pulmonary disease, has limited sensitivity for early identification of tobacco-exposed individuals with preserved spirometry (TEPS) at risk for respiratory decline. We aimed to determine whether abnormalities in residual volume to total lung capacity ratio (RV/TLC) and total lung capacity (TLC) identify TEPS at higher risk of subsequent spirometric decline.
methods1986 tobacco-exposed individuals (≥ 25 years, ≥ 10 pack-years) with preserved spirometry (FEV
resultsHigh RV/TLC (≥ upper limit of normal, ULN, z-scores > + 1.645) was present in 6.5% of TEPS, predominantly with normal TLC (87.6%) and associated with greater smoking intensity. Notably, elevated RV/TLC associated with disproportionate declines in FEV1/FVC driven by discordant reductions in FEV
conclusionThese findings underscore the limitations of spirometry alone and advocate for routine lung volume assessment in at-risk smokers.
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