Evidence map›Paper›PMID 41832325›Full record

ArticleMikrochimica acta2026

Gold nanoparticles-modulated ECL/PEC aptasensor for the dual-mode detection of Alzheimer's disease biomarker.

Shuna Zhai, Pei Zhang, Chunhong Shen, Ruowei Wang, Jihua Tang, Qiumei Feng, Jiliang Zhai

Abstract read
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In one paragraph

Article in Mikrochimica acta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shuna ZhaiSchool of Nursing, Shandong Xiehe University, No.6277 Jiqing Road, Jinan, 250109, China.
Pei ZhangSchool of Nursing, Shandong Xiehe University, No.6277 Jiqing Road, Jinan, 250109, China.
Chunhong ShenSchool of Nursing, Shandong Xiehe University, No.6277 Jiqing Road, Jinan, 250109, China.
Ruowei WangSchool of Nursing, Shandong Xiehe University, No.6277 Jiqing Road, Jinan, 250109, China.
Jihua TangSchool of Nursing, Shandong Xiehe University, No.6277 Jiqing Road, Jinan, 250109, China.
Qiumei FengSchool of Chemistry and Materials Science, Jiangsu Normal University, Xuzhou, 221116, China. fengqiumei@jsnu.edu.cn.
Jiliang ZhaiDepartment of Radiology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, 250117, China. jlnn@163.com.

Funding

Natural Science Foundation of Jiangsu Province BK20170228
6 · The paper itself

Abstract

A dual-mode electrochemiluminescent/photoelectrochemical (ECL/PEC) aptasensor modulated by optical and catalytic properties of gold nanoparticles (Au NPs) is constructed to determine soluble amyloid β oligomer (AβO), a critical Alzheimer’s disease (AD) biomarker. In this system, CdS quantum dots (QDs) are integrated onto an indium tin oxide electrode (ITO), acting as ECL emission source and PEC substrates. The developed sensing system enables signal transduction by exploiting the robust AβO binding ability of the developed aptamer and magnetic isolation as an enrichment strategy. The resultant AβO-dependent T strands can trigger the toehold-mediated strand displacement (TMSD) reaction, consequently enabling the assembly of copious P-Au NPs strands. By the modulation of localized surface plasmon resonance (LSPR) and oxidase-mimic performance of Au NPs on CdS QDs, the boosting ECL signal and quenching PEC response are both observed. Based on the above merits, the aptasensor can successfully determine the AβO level in a linear range spanning from 10 fM to 10 nM, with detection limits as low as 3.1 fM (ECL mode) and 3.3 fM (PEC mode). Furthermore, the applicability of the aptasensor is estimated for AβO detection in real cerebrospinal fluid and serum samples with acceptable signal recoveries, offering a viable, sensitive, and promising approach for the early diagnosis of AD.

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAptamers, NucleotideBiosensing TechniquesElectrochemical TechniquesMetal NanoparticlesBiomarkersCadmium CompoundsGoldHumansLimit of DetectionLuminescent MeasurementsQuantum DotsSulfidesTin CompoundsAmyloid beta-PeptidesAptamers, NucleotideBiomarkersCadmium Compoundscadmium sulfideGoldSulfidesTin CompoundsAmyloid β oligomerDual-mode aptasensorElectrochemiluminescenceLSPROxidase-mimic performancePhotoelectrochemical detectionToehold-mediated strand displacement

Identifiers

PMID41832325

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.