Evidence map›Paper›PMID 41832266›Full record

ArticleOncogene2026

LINC-AC092535.5 regulates MICAL2 mRNA level to inhibit p53-mediated ferroptosis in nasopharyngeal carcinoma.

Siyu Zhang, Wenyue Chen, Ji Yang, Zhen Ge, Yan Kong, Haiou Yan, Lili Bao, Ying Shan, Zhiyuan Yang, Wenhui Chen and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncogene, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Siyu Zhang *Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China.
Wenyue Chen *Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China.
Ji YangDepartment of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China.
Zhen GeDepartment of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China.
Yan KongThe PRC Ministry of Education Engineering Research Center of Intelligent Technology for Healthcare, Wuxi, China.
Haiou YanDepartment of Nursing, Affiliated Hospital of Nantong University, Nantong, China.
Lili BaoDepartment of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China.
Ying ShanDepartment of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China.
Zhiyuan YangDepartment of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China.
Wenhui ChenDepartment of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China.
Si PanDepartment of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China.
Yiwen YouDepartment of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China.
Bo YouDepartment of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China. youbo@ntu.edu.cn.
Qicheng ZhangDepartment of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China. qczhang_ent@163.com.ORCID http://orcid.org/0000-0003-0246-9622

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ferroptosis is a form of iron-dependent programmed cell death (PCD) that, once activated, inhibits tumor progression. However, the specific mechanisms influencing ferroptosis in nasopharyngeal carcinoma (NPC) are limited and warrant further investigation. This study proposes that MICAL2 not only influences the nuclear translocation of p53 but also facilitates the ubiquitination of p53 by recruiting the E3 ubiquitination ligase MDM2, leading to its degradation. This process inhibits ferroptosis in NPC cells, thereby promoting NPC progression and adversely affecting the prognosis of NPC patients. Additionally, we identified a novel long non-coding RNA (lncRNA), LINC-AC092535.5, which directly modulates the MICAL2 mRNA level through dual reinforcement at both transcriptional and post-transcriptional levels. Transcriptome sequencing and RACE experiments provided insights into the function of this new lncRNA. These findings will contribute to the expansion of the ferroptosis gene regulatory network and inform new clinical treatment strategies for NPC.

Indexed as

FerroptosisNasopharyngeal CarcinomaNasopharyngeal NeoplasmsRNA, Long NoncodingRNA, MessengerTumor Suppressor Protein p53Cell Line, TumorGene Expression Regulation, NeoplasticHumansProto-Oncogene Proteins c-mdm2UbiquitinationMDM2 protein, humanProto-Oncogene Proteins c-mdm2RNA, Long NoncodingRNA, MessengerTP53 protein, humanTumor Suppressor Protein p53

Identifiers

PMID41832266
PMCPMC13033448

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.