Evidence map›Paper›PMID 41832208›Full record

ArticleScientific reports2026

Analysis of immune-related alterations in blood and spinal cord of canine degenerative myelopathy, a spontaneous model of amyotrophic lateral sclerosis.

Shunya Yokota, Yui Kobatake, Kei Yoshida, Hiroaki Kamishina, Osamu Yamato, Shinichiro Maki, Kohei Nakata, Jun Sasaki, Hiroki Sakai, Junya Hirashima and 2 more

Abstract read
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In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shunya YokotaJoint Graduate School of Veterinary Sciences, Gifu University, Gifu, Gifu, Japan.
Yui KobatakeJoint Graduate School of Veterinary Sciences, Gifu University, Gifu, Gifu, Japan. kobatake.yui.h1@f.gifu-u.ac.jp.
Kei YoshidaDolphin Animal Hospital Urawa Misono Clinic, Saitama, Saitama, Japan.
Hiroaki KamishinaKyotoAR Advanced Veterinary Medical Center, Kumiyama-cho, Kyoto, Japan.
Osamu YamatoJoint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Kagoshima, Japan.
Shinichiro MakiJoint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Kagoshima, Japan.
Kohei NakataSchool of Veterinary Medicine, Iwate university, Morioka, Iwate, Japan.
Jun SasakiSchool of Veterinary Medicine, Iwate university, Morioka, Iwate, Japan.
Hiroki SakaiJoint Graduate School of Veterinary Sciences, Gifu University, Gifu, Gifu, Japan.
Junya HirashimaJoint Department of Veterinary Medicine, Faculty of Applied Biological Science, Gifu University, Gifu, Gifu, Gifu, Japan.
Satoshi TakashimaJoint Department of Veterinary Medicine, Faculty of Applied Biological Science, Gifu University, Gifu, Gifu, Gifu, Japan.
Naohito NishiiJoint Graduate School of Veterinary Sciences, Gifu University, Gifu, Gifu, Japan.

Funding

Japan Society for the Promotion of Science 19K15978
6 · The paper itself

Abstract

Canine degenerative myelopathy (DM) is an adult-onset neurodegenerative disease considered a spontaneous model of human amyotrophic lateral sclerosis (ALS). Neuroinflammation occurs in both DM and ALS, and crosstalk between the central nervous system and systemic immunity has been demonstrated in ALS. To investigate this interaction in DM, we analyzed peripheral blood and spinal cord tissues using real-time RT-PCR and immunofluorescence. In peripheral blood, mRNA expression of interleukin (IL)-18 and nod-like receptor protein 3 was significantly increased compared with intervertebral disk herniation controls. IL-10 and caspase-1 were elevated, whereas tumor necrosis factor-α was decreased relative to healthy controls. C-C motif chemokine receptor 2 expression showed a moderate negative correlation with disease duration. Immunofluorescence revealed a few transmembrane protein 119

Indexed as

Amyotrophic Lateral SclerosisSpinal CordSpinal Cord DiseasesAnimalsDisease Models, AnimalDogsFemaleMaleAmyotrophic lateral sclerosisCanine degenerative myelopathyNeurodegenerative disorderNeuroinflammationSystemic immunity

Identifiers

PMID41832208
PMCPMC13111682

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.