Evidence map›Paper›PMID 41832179›Full record

ArticleNature communications2026

Jagged-mediated lateral induction patterns Notch3 signaling within adult neural stem cell populations.

Sara Ortica, Miguel Martinez Herrera, Louis Degroux, Bastian Rochette, Nicolas Dray, Laure Bally-Cuif

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sara OrticaInstitut Pasteur, Université Paris Cité, CNRS UMR3738, Zebrafish Neurogenetics Unit, F-75015 Paris, France.ORCID http://orcid.org/0000-0002-2241-3936
Miguel Martinez HerreraInstitut Pasteur, Université Paris Cité, CNRS UMR3738, Zebrafish Neurogenetics Unit, F-75015 Paris, France.ORCID http://orcid.org/0000-0001-7844-4064
Louis DegrouxInstitut Pasteur, Université Paris Cité, CNRS UMR3738, Zebrafish Neurogenetics Unit, F-75015 Paris, France.
Bastian RochetteInstitut Pasteur, Université Paris Cité, CNRS UMR3738, Zebrafish Neurogenetics Unit, F-75015 Paris, France.
Nicolas DrayInstitut Pasteur, Université Paris Cité, CNRS UMR3738, Zebrafish Neurogenetics Unit, F-75015 Paris, France. nicolas.dray@pasteur.fr.ORCID http://orcid.org/0000-0002-2632-6004
Laure Bally-CuifInstitut Pasteur, Université Paris Cité, CNRS UMR3738, Zebrafish Neurogenetics Unit, F-75015 Paris, France. laure.bally-cuif@pasteur.fr.ORCID http://orcid.org/0000-0001-6611-6274

Funding

Agence Nationale de la Recherche (French National Research Agency) LabEx Revive ANR-10-LABX-0073EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) ERC SyG PEPS 101071786Fondation pour la Recherche Médicale (Foundation for Medical Research in France) EQU202203014636
6 · The paper itself

Abstract

In the adult brain, Notch3 signaling promotes neural stem cell (NSC) quiescence and stemness. It remains unknown how Notch3 signaling levels are controlled and relate to these NSC decisions. Here we directly measure the nuclear translocation of the Notch3 intracellular fragment (N3ICD) and quantify Notch3 signaling in NSCs of the zebrafish adult telencephalon in situ. We report that Notch3 signaling levels match NSC quiescence and stemness levels. In physical space, Notch3 signaling is patterned and high signaling levels surround N3ICD

Indexed as

Adult Stem CellsJagged-1 ProteinNeural Stem CellsReceptor, Notch3Signal TransductionZebrafish ProteinsAnimalsIntracellular Signaling Peptides and ProteinsMembrane ProteinsSOXB1 Transcription FactorsTelencephalonZebrafishdelta proteinIntracellular Signaling Peptides and ProteinsJagged-1 ProteinMembrane ProteinsNotch3 protein, zebrafishReceptor, Notch3SOXB1 Transcription FactorsZebrafish Proteins

Identifiers

PMID41832179
PMCPMC13136484

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.