Evidence map›Paper›PMID 41832165›Full record

ReviewNPJ Regenerative medicine2026

Seeing through collagen: integrative pro-regenerative corneal implants for clearer future.

Xia Huang, Mohammad M Islam, Stephanie L Watson, Hirak K Patra

Abstract readReview
In one paragraph

Review in NPJ Regenerative medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xia HuangCollege of Chemistry, Sichuan University, Chengdu, China.
Mohammad M IslamDepartment of Ophthalmology and Visual Sciences, University of New Mexico School of Medicine, Albuquerque, NM, USA.
Stephanie L WatsonSydney Medical School, The University of Sydney, Sydney, NSW, Australia.
Hirak K PatraDepartment of Surgical Biotechnology, Division of Surgery and Interventional Science, University College London, London, UK. hirak.patra@ucl.ac.uk.

Funding

Mesenchymal Stem Cells can Restore and Maintain Corneal Endothelial FunctionR00EY031373 · NEI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Mohammad Mirazul Islam · 2024 to 2026
$746k
Medical Research Council MR/T030968/1NEI NIH HHS R00 EY031373NIH HHS R00EY031373
6 · The paper itself

Abstract

Collagen-based artificial corneas are a promising regenerative alternative to scarce donor tissue. However, their clinical success is limited by mechanical weakness, enzymatic degradation, and poor bio-integration. This review provides a comprehensive analysis of the current state and the future strategies to optimize collagen for making pro-regenerative corneal implants, enhancing the performance, functionality, and clinical viability of the collagen-based artificial cornea as a substitute for donor tissue.

Identifiers

PMID41832165
PMCPMC13133174

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.