Evidence map›Paper›PMID 41832154›Full record

ArticleNature communications2026

Dopamine and serotonin inversely modulate D2 medium spiny neurons to regulate cocaine reward.

Daniel F Cardozo Pinto, Michaela Y Guo, Matthew B Pomrenze, Wade Morishita, Mona X Li, Larry S Zweifel, Neir Eshel, Robert C Malenka

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Daniel F Cardozo Pinto *Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA. dcardozopinto@fas.harvard.edu.ORCID http://orcid.org/0000-0002-6104-4643
Michaela Y Guo *Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0009-0008-2835-3242
Matthew B PomrenzeNancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-9032-5911
Wade MorishitaNancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Mona X LiNancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0009-0005-0411-6427
Larry S ZweifelDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-3465-5331
Neir EshelDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA. neshel@stanford.edu.ORCID http://orcid.org/0000-0002-5976-2013
Robert C MalenkaNancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA. malenka@stanford.edu.ORCID http://orcid.org/0000-0002-5428-5211

Funding

Training CoreP50DA042012 · NIDA · STANFORD UNIVERSITY · PI Karl A. Deisseroth · 2017 to 2026
$27.1M
University of Washington Center of Excellence in Opioid Addiction ResearchP30DA048736 · NIDA · UNIVERSITY OF WASHINGTON · PI Charles Chavkin · 2019 to 2026
$13.0M
Serotonergic modulation of aggressive and prosocial behaviorsR01MH138645 · NIMH · STANFORD UNIVERSITY · PI Neir Eshel · 2025 to 2026
$1.3M
Neural circuits of frustrationK08MH123791 · NIMH · STANFORD UNIVERSITY · PI ESHEL, NEIR · 2020 to 2024
$1.2M
Modulation of protracted opioid withdrawal by dorsal raphe dynorphin neuronsK99DA056573 · NIDA · STANFORD UNIVERSITY · PI POMRENZE, MATTHEW B · 2022 to 2023
$317k
Brain and Behavior Research Foundation (Brain & Behavior Research Foundation) Young Investigator GrantBurroughs Wellcome Fund (BWF) Career Award for Medical ScientistsHoward Hughes Medical Institute (HHMI) Gilliam FellowshipNIDA NIH HHS K99 DA056573NIDA NIH HHS P30 DA048736NIDA NIH HHS P50 DA042012NIMH NIH HHS K08 MH123791NIMH NIH HHS R01 MH138645Simons Foundation Bridge to Independence AwardU.S. Department of Health & Human Services | National Institutes of Health (NIH) K08MH123791U.S. Department of Health & Human Services | National Institutes of Health (NIH) K99DA056573U.S. Department of Health & Human Services | National Institutes of Health (NIH) P30DA048736U.S. Department of Health & Human Services | National Institutes of Health (NIH) P50DA042012U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01MH138645
6 · The paper itself

Abstract

Classic theories propose opponent functions for striatal dopamine (DA) and serotonin (5-hydroxytryptamine; 5HT), with DA promoting approach and 5HT promoting patience or avoidance. How these neuromodulators regulate downstream circuits to achieve such antagonistic effects remains mysterious. Here, we mapped striatal 5HT receptor expression in mice to reveal preferential enrichment of putatively excitatory, G

Indexed as

CocaineDopamineMedium Spiny NeuronsReceptors, Dopamine D2RewardSerotoninAnimalsCorpus StriatumMaleMiceMice, Inbred C57BLNeuronsReceptor, Serotonin, 5-HT2AReceptor, Serotonin, 5-HT2CCocaineDopamineDRD2 protein, mouseReceptors, Dopamine D2Receptor, Serotonin, 5-HT2AReceptor, Serotonin, 5-HT2CSerotonin

Identifiers

PMID41832154
PMCPMC13133351

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.