Evidence map›Paper›PMID 41832141›Full record

ArticleNature communications2026

Single-cell and spatial profiling reveal cDC2A-CXCL13

Rundong Jiang, Rachael Bogle, Xianying Xing, Joseph Kirma, Jennifer Fox, Paul W Harms, Tran Do, Allison C Billi, J Michelle Kahlenberg, Robert L Modlin and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Rundong JiangDepartment of Dermatology, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0009-0006-8296-4912
Rachael BogleDepartment of Dermatology, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0003-3544-3023
Xianying XingDepartment of Dermatology, University of Michigan, Ann Arbor, MI, USA.
Joseph KirmaDepartment of Dermatology, University of Michigan, Ann Arbor, MI, USA.
Jennifer FoxDepartment of Dermatology, University of Michigan, Ann Arbor, MI, USA.
Paul W HarmsDepartment of Dermatology, University of Michigan, Ann Arbor, MI, USA.
Tran DoDepartment of Dermatology, University of Michigan, Ann Arbor, MI, USA.
Allison C BilliDepartment of Dermatology, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-7115-9113
J Michelle KahlenbergDepartment of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-4006-8945
Robert L ModlinDepartment of Dermatology, University of California Los Angeles (UCLA), Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-4720-031X
Rosane TelesDepartment of Dermatology, University of California Los Angeles (UCLA), Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-2908-3244
Julie WestDepartment of Dermatology, University of California Los Angeles (UCLA), Los Angeles, CA, USA.ORCID http://orcid.org/0009-0004-6089-8948
Aaron MangoldDepartment of Dermatology, Mayo Clinic, Scottsdale, AZ, USA.
Haihan ZhangDepartment of Biostatistics, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-5902-7289
Martin A SchneiderImmunology Disease Area, Novartis BioMedical Research, Novartis Pharma AG, Basel, Switzerland.
Sandro BrunoImmunology Disease Area, Novartis BioMedical Research, Novartis Pharma AG, Basel, Switzerland.
Ben RoedigerImmunology Disease Area, Novartis BioMedical Research, Novartis Pharma AG, Basel, Switzerland.ORCID http://orcid.org/0000-0002-4593-091X
Georg Martiny-BaronImmunology Disease Area, Novartis BioMedical Research, Novartis Pharma AG, Basel, Switzerland.ORCID http://orcid.org/0009-0008-1221-8097
Lam C TsoiDepartment of Dermatology, University of Michigan, Ann Arbor, MI, USA.
Feriel Hacini-RachinelImmunology Disease Area, Novartis BioMedical Research, Novartis Pharma AG, Basel, Switzerland.ORCID http://orcid.org/0000-0002-8052-2997
Till A RöhnImmunology Disease Area, Novartis BioMedical Research, Novartis Pharma AG, Basel, Switzerland.
Johann E GudjonssonDepartment of Dermatology, University of Michigan, Ann Arbor, MI, USA. johanng@med.umich.edu.ORCID http://orcid.org/0000-0002-0080-0812

Funding

Microbiology and Metagenomics CoreP50AR080594 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROBERT L MODLIN · 2022 to 2026
$9.2M
NIAMS NIH HHS P50 AR080594
6 · The paper itself

Abstract

Lichen planus (LP) is a chronic inflammatory disease of the skin and mucous membranes, marked by T cell infiltration and keratinocyte apoptosis. However, its immune microenvironment remains poorly understood. Using single-cell RNA sequencing, spatial transcriptomics, and proteomics on samples from 28 patients and 18 healthy controls, we identify elevated interferon (IFN) and cytotoxic signatures in CXCL13

Indexed as

CD8-Positive T-LymphocytesChemokine CXCL13Epithelial CellsLichen PlanusFemaleHumansInterferon-gammaInterleukin-15MaleMucous MembraneSingle-Cell AnalysisSingle-Cell Gene Expression AnalysisSkinChemokine CXCL13Interferon-gammaInterleukin-15

Identifiers

PMID41832141
PMCPMC13133274

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.