Evidence map›Paper›PMID 41831802›Full record

ArticleFree radical biology & medicine2026

Aldh3a1-mediated detoxification of reactive aldehydes contributes to distinct muscle responses to amyotrophic lateral sclerosis progression.

Ang Li, Li Dong, Xuejun Li, Jianxun Yi, Jo-Yu Wu, Jianjie Ma, Jingsong Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Free radical biology & medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Ang LiDepartment of Kinesiology, College of Nursing and Health Innovation, University of Texas at Arlington, TX, 76019, USA. Electronic address: ang.li3@uta.edu.
Li DongDepartment of Kinesiology, College of Nursing and Health Innovation, University of Texas at Arlington, TX, 76019, USA.
Xuejun LiDepartment of Kinesiology, College of Nursing and Health Innovation, University of Texas at Arlington, TX, 76019, USA.
Jianxun YiDepartment of Kinesiology, College of Nursing and Health Innovation, University of Texas at Arlington, TX, 76019, USA.
Jo-Yu WuDepartment of Kinesiology, College of Nursing and Health Innovation, University of Texas at Arlington, TX, 76019, USA.
Jianjie MaDepartment of Surgery, Division of Surgical Sciences, University of Virginia, Charlottesville, VA, 22903, USA.
Jingsong ZhouDepartment of Kinesiology, College of Nursing and Health Innovation, University of Texas at Arlington, TX, 76019, USA. Electronic address: jingsong.zhou@uta.edu.

Funding

Preserving Mitochondrial Function for Alleviating ALS ProgressionR01NS105621 · NINDS · UNIVERSITY OF TEXAS ARLINGTON · PI BROTTO, MARCO, ZHOU, JINGSONG · 2019 to 2023
$2.9M
Multifaceted role of MG53 in alleviating neuromuscular function decline in ALSR01NS129219 · NINDS · UNIVERSITY OF TEXAS ARLINGTON · PI Jianjie Ma, Lyle Wilfred Ostrow · 2023 to 2026
$2.5M
NINDS NIH HHS R01 NS105621NINDS NIH HHS R01 NS129219
6 · The paper itself

Abstract

Different muscles exhibit varied susceptibility to degeneration in Amyotrophic Lateral Sclerosis (ALS), a fatal neuromuscular disorder. Extraocular muscles (EOMs) are particularly resistant to ALS progression, and exploring the underlying molecular nature may offer significant therapeutic value. Reactive aldehyde 4-hydroxynonenal (HNE) is implicated in ALS pathogenesis, and Aldh3a1 is an inactivation-resistant intracellular aldehyde dehydrogenase that detoxifies 4-HNE to protect eyes against UV-induced oxidative stress. We detected prominently higher levels of Aldh3a1 in mouse EOMs compared to other muscles under normal physiological conditions. In an ALS mouse model (hSOD1

Indexed as

Aldehyde DehydrogenaseAldehydesAmyotrophic Lateral SclerosisMuscle, SkeletalAnimalsDisease Models, AnimalDisease ProgressionHumansMiceMice, TransgenicOxidative Stress4-hydroxy-2-nonenalAldehyde DehydrogenaseAldehydesAldh3a1 protein, mouseAldehyde dehydrogenaseAmyotrophic lateral sclerosisExtraocular muscleReactive aldehydesSciatic nerve transectionSkeletal muscle

Identifiers

PMID41831802
PMCPMC13218201

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.