Evidence map›Paper›PMID 41831719›Full record

ArticleClinical nutrition ESPEN2026

Influence of ginger root extract supplementation on the microbiota-gut-brain axis in individuals with sciatica: Study protocol for a double-blind, placebo-controlled randomized trial.

Chwan-Li Shen, Moamen M Elmassry, Chanaka Kahathuduwa, Jaehoon Lee, Miles R Day, David S Edwards, Harshit Parmar, Tor D Wager, Xiaobo Liu, Melanie Baccus and 2 more

Abstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical nutrition ESPEN, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Chwan-Li ShenDepartment of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA; Center of Excellence for Integrative Health, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA; Center of Excellence for Translational Neuroscience and Therapeutics, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA; Obesity Research Institute, Texas Tech University, Lubbock, TX, 79409, USA. Electronic address: leslie.shen@ttuhsc.edu.
Moamen M ElmassryDepartment of Molecular Biology, Princeton University, Princeton, NJ 08540, USA. Electronic address: elmassry@princeton.edu.
Chanaka KahathuduwaCenter of Excellence for Integrative Health, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA; Center of Excellence for Translational Neuroscience and Therapeutics, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA; Department of Neurology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA. Electronic address: chanaka.kahathuduwa@ttuhsc.edu.
Jaehoon LeeCenter of Excellence for Integrative Health, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA; Department of Educational Psychology and Leadership, Texas Tech University, Lubbock, TX, 79409, USA. Electronic address: jaehoon.lee@ttu.edu.
Miles R DayDepartment of Anesthesiology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA. Electronic address: miles.day@ttuhsc.edu.
David S EdwardsDepartment of Family and Community Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA. Electronic address: david.s.edwards@ttuhsc.edu.
Harshit ParmarTexas Tech Neuroimaging Institute, Texas Tech University, Lubbock, TX, 79409, USA. Electronic address: harshit.parmar@ttu.edu.
Tor D WagerDepartment of Psychological and Brain Sciences, Dartmouth College, Hanover, NH 03755, USA. Electronic address: tor.d.wager@dartmouth.edu.
Xiaobo LiuDepartment of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA. Electronic address: xiaobo.liu@ttuhsc.edu.
Melanie BaccusClinical Research Institute, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA. Electronic address: melanie.baccus@ttuhsc.edu.
Abdul HamoodDepartment of Immunology and Molecular Microbiology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA. Electronic address: abdul.hamood@ttuhsc.edu.
Volker NeugebauerCenter of Excellence for Integrative Health, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA; Center of Excellence for Translational Neuroscience and Therapeutics, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA; Department of Pharmacology and Neuroscience, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA; Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA. Electronic address: volker.neugebauer@ttuhsc.edu.

Funding

PAIN, NOCICEPTION, AND THE AMYGDALAR01NS038261 · NINDS · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI Volker Neugebauer, Igor Ponomarev · 1999 to 2026
$8.7M
NINDS NIH HHS R01 NS038261
6 · The paper itself

Abstract

Neuropathic pain (NP) is caused by damage to the peripheral or central nervous system and is associated with adverse complex sensory and affective symptoms. There are few current treatment options for NP, and opioid analgesics have severe side effects which can lead to opioid abuse. Therefore, the development of innovative, effective, and safe alternatives is urgently needed. This study will assess the effects of ginger root extract's anti-inflammatory and anti-oxidant properties on individuals with sciatica via the microbiome-gut-brain axis. Eighty participants (18-85 years) with chronic sciatica, classified as lean (n = 40, BMI <25 kg/m

Indexed as

BrainDietary SupplementsGastrointestinal MicrobiomePlant ExtractsSciaticaZingiber officinaleAdolescentAdultAgedAged, 80 and overDouble-Blind MethodFemaleHumansMaleMiddle AgedPlant Rootsginger extractPlant ExtractsFecal metabolitesGingerGut-brain-axisMicrobiomeNeuroinflammationNeuropathic pain

Identifiers

PMID41831719
PMCPMC13489092

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.