Evidence map›Paper›PMID 41831133›Full record

ArticleJournal of muscle research and cell motility2026

Resistance-based exercise restores muscle health in dialysis patients.

Piush Srivastava, Sunil Kumar Singh, Rakesh Sathish Nair, Saket Jha, Navin Viswakarma, Deepti Srivastava, Greg Hachaj, Stephen T Bartlett, Ilaria Santi, Aslam Ejaz and 4 more

Abstract read
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In one paragraph

Article in Journal of muscle research and cell motility, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Piush Srivastava *Department of Surgery, College of Medicine, University of Illinois Chicago, 840 S. Wood Street, Chicago, IL, 60612, USA.
Sunil Kumar Singh *Department of Surgery, College of Medicine, University of Illinois Chicago, 840 S. Wood Street, Chicago, IL, 60612, USA.
Rakesh Sathish NairDepartment of Surgery, College of Medicine, University of Illinois Chicago, 840 S. Wood Street, Chicago, IL, 60612, USA.
Saket JhaDepartment of Surgery, College of Medicine, University of Illinois Chicago, 840 S. Wood Street, Chicago, IL, 60612, USA.
Navin ViswakarmaDepartment of Surgery, College of Medicine, University of Illinois Chicago, 840 S. Wood Street, Chicago, IL, 60612, USA.
Deepti SrivastavaDepartment of Surgery, College of Medicine, University of Illinois Chicago, 840 S. Wood Street, Chicago, IL, 60612, USA.
Greg HachajDepartment of Surgery, College of Medicine, University of Illinois Chicago, 840 S. Wood Street, Chicago, IL, 60612, USA.
Stephen T BartlettDepartment of Surgery, College of Medicine, University of Illinois Chicago, 840 S. Wood Street, Chicago, IL, 60612, USA.
Ilaria SantiDepartment of Surgery, College of Medicine, University of Illinois Chicago, 840 S. Wood Street, Chicago, IL, 60612, USA.
Aslam EjazDepartment of Surgery, College of Medicine, University of Illinois Chicago, 840 S. Wood Street, Chicago, IL, 60612, USA.
Robert W MotlDepartment of Kinesiology and Nutrition, College of Applied Health Sciences, University of Illinois Chicago, Chicago, Chicago, Illinois, IL, 60612, USA.
Enrico BenedettiDepartment of Surgery, College of Medicine, University of Illinois Chicago, 840 S. Wood Street, Chicago, IL, 60612, USA.
Sandeep KumarDepartment of Surgery, College of Medicine, University of Illinois Chicago, 840 S. Wood Street, Chicago, IL, 60612, USA. ksandeep@uic.edu.
Ajay RanaDepartment of Surgery, College of Medicine, University of Illinois Chicago, 840 S. Wood Street, Chicago, IL, 60612, USA. arana@uic.edu.

Funding

BLRD VA IK6 BX004855
6 · The paper itself

Abstract

Chronic kidney disease (CKD) and end-stage renal disease (ESRD) are serious health concerns worldwide that require regular dialysis before a kidney transplant for a better quality of life. Due to aging and frailty, dialysis patients are often limited in physical activity, which can lead to multiple health complications and sometimes result in patient death. Therefore, maintaining muscle health is crucial for individuals undergoing dialysis. We recently reported that personalized resistance-based exercise can improve frailty in dialysis patients; however, the molecular mechanisms underlying its effects on muscle health remain unknown. RNA-Seq analysis revealed that exercise upregulates genes associated with muscle stemness, regeneration, and differentiation. Furthermore, our study demonstrated that exercise upregulates mitochondrial proteins involved in the oxidation of organic compounds and mitochondrial function in muscle. Moreover, we observed that exercise increased energy production via glucose uptake, glycogenesis, and fatty acid metabolism. These results suggest that personalized resistance-based muscle therapy in dialysis patients restores the expression of genes and proteins associated with muscle stemness, regeneration, differentiation, and energy generation.

Indexed as

ExerciseKidney Failure, ChronicMuscle, SkeletalRenal DialysisResistance TrainingHumansDialysisFrailtyMuscle functionMuscle regenerationPersonalized exerciseSkeletal muscle

Identifiers

PMID41831133
PMCPMC12989000

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.