ArticleEuropean child & adolescent psychiatry2026
Knock down the first domino: in silico intervention for age-tailored prevention and treatment targets in adolescent mental health.
Article in European child & adolescent psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Wellbeing While Waiting: Effectiveness and implementation of youth social prescribing for young people awaiting CAMHS support.European child & adolescent psychiatry · 2026Article
- A network analysis of short video addiction and inattention symptoms among undergraduate nursing students.BMC nursing · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundAdolescence is a critical developmental period characterized by significant challenges, a time of "storm and stress". The complex system of multidimensional mental health problems may vary across early, middle, and late adolescence due to the distinctive developmental tasks. However, previous efforts to identify prevention and treatment targets mainly focused on limited aspects of such a system and lacked age-specific considerations.
objectiveThis study aims to identify pivotal age-tailored treatment and prevention targets for multidimensional mental health problems through dynamic simulation.
methodsThree stage-specific between-subject networks were constructed to model mental health problems, using data from 80,113 Chinese adolescents. In silico intervention was implemented on these networks to identify particular symptoms that, if targeted, would prove most effective in either preventing (via aggravating simulation) or treating (via alleviating simulation) mental health issues within the mental health system.
resultsStage-specific in silico intervention analysis revealed that, during early adolescence, academic stress and interpersonal sensitivity were the most effective targets in aggravating and alleviating interventions, respectively. In middle and late adolescence, anxiety emerged as the most significant target for aggravation, while emotional disturbance demonstrated the greatest alleviating effect. CONCLUSIONS AND IMPLICATIONS: Academic stress experienced during early adolescence and anxiety prevalent in middle to late adolescence are recommended as primary prevention targets. Interpersonal sensitivity emerges as the most effective treatment target for early adolescents, whereas emotional disturbance should be prioritized for middle to late adolescents.
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Registered trials
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